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Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis.

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Title: Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis.
Authors: Duffen JL; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA. Jennifer.Duffen@pfizer.com., Crouse KK; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Ji L; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Brault AL; Medicine Design, Pfizer Inc, Groton, CT, USA., Ford K; Medicine Design, Pfizer Inc, Groton, CT, USA., Brooks J; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Jelinsky SA; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Li Y; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Shin JH; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Zhao Y; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Andreyeva T; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Hammerman K; Drug Safety Research and Development, Pfizer Inc, Cambridge, MA, USA., Arnold C; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Sheldon RT; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Garren J; Data Sciences and Analytics, Pfizer Inc, Cambridge, MA, USA., LaBarge W; MedPharm Ltd, Durham, NC, USA., Resek A; MedPharm Ltd, Durham, NC, USA., Volmer J; MedPharm Ltd, Durham, NC, USA., Bagley SW; Medicine Design, Pfizer Inc, Groton, CT, USA., Casimiro-Garcia A; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Chinigo GM; Medicine Design, Pfizer Inc, Groton, CT, USA., Davoren JE; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Denny RA; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Drozda S; Medicine Design, Pfizer Inc, Groton, CT, USA., Foley TL; Medicine Design, Pfizer Inc, Groton, CT, USA., Hicklin RW; Medicine Design, Pfizer Inc, Groton, CT, USA., Liu S; Medicine Design, Pfizer Inc, Groton, CT, USA., Lovering FE; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Nedoma NL; Medicine Design, Pfizer Inc, Groton, CT, USA., Parikh MD; Medicine Design, Pfizer Inc, Groton, CT, USA., Strohbach JW; Medicine Design, Pfizer Inc, Cambridge, MA, USA., Trujillo JI; Medicine Design, Pfizer Inc, Groton, CT, USA., Steyn SJ; Pharmacokinetics, Dynamics, and Metabolism, Pfizer Inc, Cambridge, MA, USA., Nocka K; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Hegen M; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Vincent F; Medicine Design, Pfizer Inc, Groton, CT, USA., Lee KL; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA., Gerstenberger BS; Medicine Design, Pfizer Inc, Cambridge, MA, USA. Brian.Gerstenberger@pfizer.com., Primiano MJ; Inflammation and Immunology, Pfizer Inc, Cambridge, MA, USA.
Source: Nature communications [Nat Commun] 2026 Mar 09; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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