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Does stringent cytoreduction improve survival in advanced proliferative chronic myelomonocytic leukemia?

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Title: Does stringent cytoreduction improve survival in advanced proliferative chronic myelomonocytic leukemia?
Authors: Selimoglu-Buet D; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France., Chevret S; Service de Biostatistique et informatique médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.; Université Paris Cité, Institut de Recherche Saint-Louis UMR1342, INSERM, CNRS, F-75010, Paris, France.; Leukemia Institute Paris Saint-Louis, Paris, France., Santini V; MDS Unit, DMSC; AOU Careggi, University of Florence, Florence, Italy.; Fondazione Italiana Sindromi Mielodisplastiche (FISiM-ets), Bologna, Italy., Thépot S; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Hematology Department CHU Angers, Université Angers, Angers, France., Morabito M; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France., Adès L; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Paris Cité, Institut de Recherche Saint-Louis UMR1342, INSERM, CNRS, F-75010, Paris, France.; Leukemia Institute Paris Saint-Louis, Paris, France.; Service Hématologie Seniors, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France., Laplane L; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.; CNRS, Institut d'Histoire et Philosophie des Sciences et des Techniques, University Paris 1 Panthéon-Sorbonne, Paris, France., Giagounidis A; Marien Hospital, Klinik für Hämatologie, Onkologie und klinische Immunologie, D-40479, Düsseldorf, Germany.; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany., Droin N; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France., Lübbert M; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine - University Medical Center Freiburg, D-79106, Freiburg, Germany., Sapena R; Groupe Francophone des Myélodysplasies, F-75010, Paris, France., Nimubona S; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Service Hématologie Clinique adulte, CHU de Rennes, F-35000, Rennes, France., Torregrosa-Diaz JM; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Service d'Hématologie Oncologique et Thérapie Cellulaire, CIC INSERM 1402, University Hospital of Poitiers, Poitiers, France., Germing U; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Heinrich-Heine University Düsseldorf, Universitätsklinik Düsseldorf, Klinik für Hämatologie, Onkologie und Klinische Immunologie, D-40225, Düsseldorf, Germany., Pelizzari AM; Fondazione Italiana Sindromi Mielodisplastiche (FISiM-ets), Bologna, Italy.; Hematology Unit, ASST Spedali Civili, I-25123, Brescia, Italy., Park S; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Grenoble Alpes, Hematology Department, CHU Grenoble Alpes, Grenoble, France., Jaekel N; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; University Hospital Halle, University Medicine Halle (Saale), D-06120, Halle (Saale), Germany., Metzgeroth G; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Onida F; Fondazione Italiana Sindromi Mielodisplastiche (FISiM-ets), Bologna, Italy.; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - ASST Fatebenefratelli-Sacco - University of Milan, Milan, Italy., Paul F; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Service d'Hématologie, CHU Montpellier, Montpellier, France., Patriarca A; Fondazione Italiana Sindromi Mielodisplastiche (FISiM-ets), Bologna, Italy.; Hematology Unit, AOU «Maggiore della Carità » and University of Eastern Piedmont, I-28100, Novara, Italy., Stamatoullas A; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Centre Henri Becquerel, F-76038, Rouen, France., Götze K; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Technical University of Munich, Department of Medicine III, Munich, Germany., Chermat F; Service de Biostatistique et informatique médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France., Platzbecker U; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Universitätsklinikum Carl Gustav Carus, Dresden, Germany., Fenaux P; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Paris Cité, Institut de Recherche Saint-Louis UMR1342, INSERM, CNRS, F-75010, Paris, France.; Leukemia Institute Paris Saint-Louis, Paris, France.; Service Hématologie Seniors, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France., Solary E; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.; Department of Hematology, Gustave Roussy Cancer Center, Villejuif, France., Itzykson R; Groupe Francophone des Myélodysplasies, F-75010, Paris, France. raphael.itzykson@aphp.fr.; Université Paris Cité, Institut de Recherche Saint-Louis UMR1342, INSERM, CNRS, F-75010, Paris, France. raphael.itzykson@aphp.fr.; Leukemia Institute Paris Saint-Louis, Paris, France. raphael.itzykson@aphp.fr.; Service Hématologie Adultes, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France. raphael.itzykson@aphp.fr.
Source: Leukemia [Leukemia] 2026 Apr; Vol. 40 (4), pp. 806-815. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Does stringent cytoreduction improve survival in advanced proliferative chronic myelomonocytic leukemia?
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  Data: <searchLink fieldCode="AU" term="%22Selimoglu-Buet+D%22">Selimoglu-Buet D</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Chevret+S%22">Chevret S</searchLink>; Service de Biostatistique et informatique médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.; Université Paris Cité, Institut de Recherche Saint-Louis UMR1342, INSERM, CNRS, F-75010, Paris, France.; Leukemia Institute Paris Saint-Louis, Paris, France.<br /><searchLink fieldCode="AU" term="%22Santini+V%22">Santini V</searchLink>; MDS Unit, DMSC; AOU Careggi, University of Florence, Florence, Italy.; Fondazione Italiana Sindromi Mielodisplastiche (FISiM-ets), Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Thépot+S%22">Thépot S</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Hematology Department CHU Angers, Université Angers, Angers, France.<br /><searchLink fieldCode="AU" term="%22Morabito+M%22">Morabito M</searchLink>; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Adès+L%22">Adès L</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Paris Cité, Institut de Recherche Saint-Louis UMR1342, INSERM, CNRS, F-75010, Paris, France.; Leukemia Institute Paris Saint-Louis, Paris, France.; Service Hématologie Seniors, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.<br /><searchLink fieldCode="AU" term="%22Laplane+L%22">Laplane L</searchLink>; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.; CNRS, Institut d'Histoire et Philosophie des Sciences et des Techniques, University Paris 1 Panthéon-Sorbonne, Paris, France.<br /><searchLink fieldCode="AU" term="%22Giagounidis+A%22">Giagounidis A</searchLink>; Marien Hospital, Klinik für Hämatologie, Onkologie und klinische Immunologie, D-40479, Düsseldorf, Germany.; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Droin+N%22">Droin N</searchLink>; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Lübbert+M%22">Lübbert M</searchLink>; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine - University Medical Center Freiburg, D-79106, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sapena+R%22">Sapena R</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.<br /><searchLink fieldCode="AU" term="%22Nimubona+S%22">Nimubona S</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Service Hématologie Clinique adulte, CHU de Rennes, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Torregrosa-Diaz+JM%22">Torregrosa-Diaz JM</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Service d'Hématologie Oncologique et Thérapie Cellulaire, CIC INSERM 1402, University Hospital of Poitiers, Poitiers, France.<br /><searchLink fieldCode="AU" term="%22Germing+U%22">Germing U</searchLink>; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Heinrich-Heine University Düsseldorf, Universitätsklinik Düsseldorf, Klinik für Hämatologie, Onkologie und Klinische Immunologie, D-40225, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Pelizzari+AM%22">Pelizzari AM</searchLink>; Fondazione Italiana Sindromi Mielodisplastiche (FISiM-ets), Bologna, Italy.; Hematology Unit, ASST Spedali Civili, I-25123, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Park+S%22">Park S</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Grenoble Alpes, Hematology Department, CHU Grenoble Alpes, Grenoble, France.<br /><searchLink fieldCode="AU" term="%22Jaekel+N%22">Jaekel N</searchLink>; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; University Hospital Halle, University Medicine Halle (Saale), D-06120, Halle (Saale), Germany.<br /><searchLink fieldCode="AU" term="%22Metzgeroth+G%22">Metzgeroth G</searchLink>; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Onida+F%22">Onida F</searchLink>; Fondazione Italiana Sindromi Mielodisplastiche (FISiM-ets), Bologna, Italy.; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - ASST Fatebenefratelli-Sacco - University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Paul+F%22">Paul F</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Service d'Hématologie, CHU Montpellier, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Patriarca+A%22">Patriarca A</searchLink>; Fondazione Italiana Sindromi Mielodisplastiche (FISiM-ets), Bologna, Italy.; Hematology Unit, AOU «Maggiore della Carità » and University of Eastern Piedmont, I-28100, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Stamatoullas+A%22">Stamatoullas A</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Centre Henri Becquerel, F-76038, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Götze+K%22">Götze K</searchLink>; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Technical University of Munich, Department of Medicine III, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Chermat+F%22">Chermat F</searchLink>; Service de Biostatistique et informatique médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.<br /><searchLink fieldCode="AU" term="%22Platzbecker+U%22">Platzbecker U</searchLink>; Deutsche MDS-Studiengruppe, D-04103, Leipzig, Germany.; Universitätsklinikum Carl Gustav Carus, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Fenaux+P%22">Fenaux P</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Paris Cité, Institut de Recherche Saint-Louis UMR1342, INSERM, CNRS, F-75010, Paris, France.; Leukemia Institute Paris Saint-Louis, Paris, France.; Service Hématologie Seniors, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.<br /><searchLink fieldCode="AU" term="%22Solary+E%22">Solary E</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France.; Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.; Department of Hematology, Gustave Roussy Cancer Center, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Itzykson+R%22">Itzykson R</searchLink>; Groupe Francophone des Myélodysplasies, F-75010, Paris, France. raphael.itzykson@aphp.fr.; Université Paris Cité, Institut de Recherche Saint-Louis UMR1342, INSERM, CNRS, F-75010, Paris, France. raphael.itzykson@aphp.fr.; Leukemia Institute Paris Saint-Louis, Paris, France. raphael.itzykson@aphp.fr.; Service Hématologie Adultes, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France. raphael.itzykson@aphp.fr.
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