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Structural basis of allosteric activation of Mycobacterium tuberculosis isocitrate lyase 2.

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Title: Structural basis of allosteric activation of Mycobacterium tuberculosis isocitrate lyase 2.
Authors: Huang EY; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.; School of BioSciences, The University of Melbourne, Parkville, VIC, Australia., Kwai BXC; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia. brooke.kwai@monash.edu.; School of Chemical Sciences, The University of Auckland, Auckland, New Zealand. brooke.kwai@monash.edu.; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. brooke.kwai@monash.edu., Jiao W; Ferrier Research Institute, Victoria University of Wellington, Wellington, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand., Taka J; Laboratory of Microbial Biochemistry and Biotechnology, School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Wilde KL; National Deuteration Facility, Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia., Sethi A; The Australian Synchrotron, Australian Nuclear Science Technology Organisation, Clayton, VIC, Australia., Maher MJ; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC, Australia., Bashiri G; Laboratory of Microbial Biochemistry and Biotechnology, School of Biological Sciences, The University of Auckland, Auckland, New Zealand., Leung IKH; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia. ivanhoe.leung@unimelb.edu.au.; School of Chemical Sciences, The University of Auckland, Auckland, New Zealand. ivanhoe.leung@unimelb.edu.au.
Source: Communications biology [Commun Biol] 2026 Mar 09; Vol. 9 (1). Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural basis of allosteric activation of Mycobacterium tuberculosis isocitrate lyase 2.
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  Data: <searchLink fieldCode="AU" term="%22Huang+EY%22">Huang EY</searchLink>; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.; School of BioSciences, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kwai+BXC%22">Kwai BXC</searchLink>; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia. brooke.kwai@monash.edu.; School of Chemical Sciences, The University of Auckland, Auckland, New Zealand. brooke.kwai@monash.edu.; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia. brooke.kwai@monash.edu.<br /><searchLink fieldCode="AU" term="%22Jiao+W%22">Jiao W</searchLink>; Ferrier Research Institute, Victoria University of Wellington, Wellington, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Taka+J%22">Taka J</searchLink>; Laboratory of Microbial Biochemistry and Biotechnology, School of Biological Sciences, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Wilde+KL%22">Wilde KL</searchLink>; National Deuteration Facility, Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Sethi+A%22">Sethi A</searchLink>; The Australian Synchrotron, Australian Nuclear Science Technology Organisation, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Maher+MJ%22">Maher MJ</searchLink>; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia.; Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Bashiri+G%22">Bashiri G</searchLink>; Laboratory of Microbial Biochemistry and Biotechnology, School of Biological Sciences, The University of Auckland, Auckland, New Zealand.<br /><searchLink fieldCode="AU" term="%22Leung+IKH%22">Leung IKH</searchLink>; School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC, Australia. ivanhoe.leung@unimelb.edu.au.; School of Chemical Sciences, The University of Auckland, Auckland, New Zealand. ivanhoe.leung@unimelb.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101719179%22">Communications biology</searchLink> [Commun Biol] 2026 Mar 09; Vol. 9 (1). <i>Date of Electronic Publication: </i>2026 Mar 09.
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        Value: 10.1038/s42003-026-09821-6
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              Text: 2026 Mar 09
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