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Low-dose radiotherapy remodels the tumor immune microenvironment via the cGAS-STING pathway: mechanisms, challenges, and combination therapy strategies.

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Title: Low-dose radiotherapy remodels the tumor immune microenvironment via the cGAS-STING pathway: mechanisms, challenges, and combination therapy strategies.
Authors: He Y; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China., Zeng X; Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Cancer Center, Chengdu, 610041, Sichuan Province, China., Liu Q; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China., Zhou L; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China., Tang Y; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China., Liu S; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China., Wang X; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China., Shen S; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China., Ji J; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China., Liu Z; Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Cancer Center, Chengdu, 610041, Sichuan Province, China., Li J; Division of Thoracic Tumor Multimodality Treatment, West China Hospital, Sichuan University, Cancer Center, Chengdu, 610041, Sichuan Province, China. lijiangping@wchscu.cn.
Source: Molecular cancer [Mol Cancer] 2026 Mar 10; Vol. 25 (1). Date of Electronic Publication: 2026 Mar 10.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Low-dose radiotherapy remodels the tumor immune microenvironment via the cGAS-STING pathway: mechanisms, challenges, and combination therapy strategies.
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  Data: <searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Zeng+X%22">Zeng X</searchLink>; Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Cancer Center, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Shen+S%22">Shen S</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Ji+J%22">Ji J</searchLink>; West China School of Medicine, Sichuan University, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Cancer Center, Chengdu, 610041, Sichuan Province, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Division of Thoracic Tumor Multimodality Treatment, West China Hospital, Sichuan University, Cancer Center, Chengdu, 610041, Sichuan Province, China. lijiangping@wchscu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101147698%22">Molecular cancer</searchLink> [Mol Cancer] 2026 Mar 10; Vol. 25 (1). <i>Date of Electronic Publication: </i>2026 Mar 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101147698 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-4598 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214764598%22">14764598 </searchLink><i>NLM ISO Abbreviation: </i>Mol Cancer <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar 10
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