Identification of Biological Subtypes of Friedreich Ataxia with Structural MRI-based Machine Learning.

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Title: Identification of Biological Subtypes of Friedreich Ataxia with Structural MRI-based Machine Learning.
Authors: Pontillo G; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy.; Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Penna S; Enel Group, Sevilla, Spain., Arrigoni F; Neuroimaging Unit, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy., Bender B; Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., Boesch S; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Brunetti A; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy., Cendes F; Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil., Chopra S; Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia., Corben LA; Bruce Lefroy Centre, Murdoch Children's Research Institute, Parkville, VIC, Australia.; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia., Deistung A; University Clinic and Outpatient Clinic for Radiology, Department for Radiation Medicine, University Hospital Halle (Saale), University Medicine Halle, Halle (Saale), Germany., Delatycki MB; Bruce Lefroy Centre, Murdoch Children's Research Institute, Parkville, VIC, Australia.; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.; Victorian Clinical Genetics Services, Parkville, VIC, Australia., Diciotti S; Department of Electrical, Electronic, and Information Engineering Guglielmo Marconi, University of Bologna, Bologna, Italy., Dogan I; Department of Neurology, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Center Jülich GmbH, Jülich, Germany., Egan GF; Monash Biomedical Imaging, Monash University, Melbourne, Australia., França MC Jr; Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil., Georgiou-Karistianis N; Turner Institute for Brain and Mental Health & School of Psychological Sciences, Monash University, Clayton, VIC, Australia., Göricke SL; Institute of Diagnostic and Interventional Radiology and Neuroradiology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany., Henry PG; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn., Hernandez-Castillo CR; Faculty of Computer Science, Dalhousie University, Halifax, Canada., Hutter D; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn., Joers JM; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn., Lenglet C; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn., Lindig T; Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany., Lodi R; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Functional and Molecular Neuroimaging Unit, IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy., Manners DN; Functional and Molecular Neuroimaging Unit, IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.; Department for Life Quality Sciences, University of Bologna, Bologna, Italy., Martinez ARM; Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil., Martinuzzi A; Scientific Institute, IRCCS Eugenio Medea, Conegliano-Pieve di Soligo Research Centre, Conegliano, Italy., Marzi C; Department of Statistics, Computer Science, and Applications Giuseppe Parenti, University of Florence, Florence, Italy., Mascalchi M; Department of Clinical and Experimental Biomedical Sciences Mario Serio, University of Florence, Florence, Italy., Nachbauer W; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Pane C; Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples Federico II, Naples, Italy., Peruzzo D; Neuroimaging Unit, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy., Pishardy PK; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn., Reetz K; Department of Neurology, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Center Jülich GmbH, Jülich, Germany., Rezende TJR; Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil., Romanzetti S; Department of Neurology, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Center Jülich GmbH, Jülich, Germany., Saccà F; GENESIS Department, University of Naples Federico II, Naples, Italy., Schoels L; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Schulz JB; Department of Neurology, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Center Jülich GmbH, Jülich, Germany., Stefani A; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria., Synofzik M; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Thomopoulos SI; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, Calif., Thompson PM; Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Marina del Rey, Calif., Timmann D; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany., Tonon C; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Functional and Molecular Neuroimaging Unit, IRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy., Vavla M; Scientific Institute, IRCCS Eugenio Medea, Conegliano-Pieve di Soligo Research Centre, Conegliano, Italy.; Child and Adolescent Neuropsychiatry Unit, Department of Women's and Children's Health, Padua University Hospital, Padua, Italy., Harding IH; QIMR Berghofer Medical Research Institute, Brisbane, Australia.; School of Translational Medicine, Monash University, Melbourne, Australia., Cocozza S; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy.
Source: Radiology [Radiology] 2026 Mar; Vol. 318 (3), pp. e251386.
Publication Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
Journal Info: Publisher: Radiological Society of North America Country of Publication: United States NLM ID: 0401260 Publication Model: Print Cited Medium: Internet ISSN: 1527-1315 (Electronic) Linking ISSN: 00338419 NLM ISO Abbreviation: Radiology Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Identification of Biological Subtypes of Friedreich Ataxia with Structural MRI-based Machine Learning.
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  Data: <searchLink fieldCode="AU" term="%22Pontillo+G%22">Pontillo G</searchLink>; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy.; Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Penna+S%22">Penna S</searchLink>; Enel Group, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Arrigoni+F%22">Arrigoni F</searchLink>; Neuroimaging Unit, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy.<br /><searchLink fieldCode="AU" term="%22Bender+B%22">Bender B</searchLink>; Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Boesch+S%22">Boesch S</searchLink>; Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Brunetti+A%22">Brunetti A</searchLink>; Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Cendes+F%22">Cendes F</searchLink>; Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Chopra+S%22">Chopra S</searchLink>; Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Corben+LA%22">Corben LA</searchLink>; Bruce Lefroy Centre, Murdoch Children's Research Institute, Parkville, VIC, Australia.; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Deistung+A%22">Deistung A</searchLink>; University Clinic and Outpatient Clinic for Radiology, Department for Radiation Medicine, University Hospital Halle (Saale), University Medicine Halle, Halle (Saale), Germany.<br /><searchLink fieldCode="AU" term="%22Delatycki+MB%22">Delatycki MB</searchLink>; Bruce Lefroy Centre, Murdoch Children's Research Institute, Parkville, VIC, Australia.; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.; Victorian Clinical Genetics Services, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Diciotti+S%22">Diciotti S</searchLink>; Department of Electrical, Electronic, and Information Engineering Guglielmo Marconi, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Dogan+I%22">Dogan I</searchLink>; Department of Neurology, RWTH Aachen University, Aachen, Germany.; JARA-BRAIN Institute Molecular Neuroscience and Neuroimaging, Research Center Jülich GmbH, Jülich, Germany.<br /><searchLink fieldCode="AU" term="%22Egan+GF%22">Egan GF</searchLink>; Monash Biomedical Imaging, Monash University, Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22França+MC+Jr%22">França MC Jr</searchLink>; Department of Neurology, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.; Brazilian Institute of Neuroscience and Neurotechnology (BRAINN), School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Georgiou-Karistianis+N%22">Georgiou-Karistianis N</searchLink>; Turner Institute for Brain and Mental Health & School of Psychological Sciences, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Göricke+SL%22">Göricke SL</searchLink>; Institute of Diagnostic and Interventional Radiology and Neuroradiology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Essen University Hospital, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Henry+PG%22">Henry PG</searchLink>; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn.<br /><searchLink fieldCode="AU" term="%22Hernandez-Castillo+CR%22">Hernandez-Castillo CR</searchLink>; Faculty of Computer Science, Dalhousie University, Halifax, Canada.<br /><searchLink fieldCode="AU" term="%22Hutter+D%22">Hutter D</searchLink>; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn.<br /><searchLink fieldCode="AU" term="%22Joers+JM%22">Joers JM</searchLink>; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn.<br /><searchLink fieldCode="AU" term="%22Lenglet+C%22">Lenglet C</searchLink>; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minn.<br /><searchLink fieldCode="AU" term="%22Lindig+T%22">Lindig T</searchLink>; Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Lodi+R%22">Lodi R</searchLink>; 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      – PersonEntity:
          Name:
            NameFull: Cocozza S
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: 2026 Mar
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1527-1315
          Numbering:
            – Type: volume
              Value: 318
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Radiology
              Type: main
ResultId 1