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Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients.

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Title: Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients.
Authors: Zhao L; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Apostolidis SA; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Suzuki A; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sarkar A; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Guo Q; Division of Transplantation, Department of Surgery, New York University Langone Health, New York, New York, USA., Li F; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Sagar A; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom., Fallon J; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom., Elzawahry MA; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom., Abbas SH; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom., Lanieri L; eGenesis, Cambridge, Massachusetts, USA., Getchell K; eGenesis, Cambridge, Massachusetts, USA., Low SC; eGenesis, Cambridge, Massachusetts, USA., Olthoff KM; Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Furth EE; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Keating BJ; Division of Transplantation, Department of Surgery, New York University Langone Health, New York, New York, USA., Friend P; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom., Poncz M; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Shaked A; Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA., Abrams CS; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Source: The Journal of clinical investigation [J Clin Invest] 2026 Mar 10; Vol. 136 (9). Date of Electronic Publication: 2026 Mar 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
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  Data: Graft-derived VWF drives platelet activation and thrombocytopenia during porcine liver xenotransplantation to brain-dead human recipients.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+L%22">Zhao L</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Apostolidis+SA%22">Apostolidis SA</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Suzuki+A%22">Suzuki A</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sarkar+A%22">Sarkar A</searchLink>; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Guo+Q%22">Guo Q</searchLink>; Division of Transplantation, Department of Surgery, New York University Langone Health, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Sagar+A%22">Sagar A</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fallon+J%22">Fallon J</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Elzawahry+MA%22">Elzawahry MA</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Abbas+SH%22">Abbas SH</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lanieri+L%22">Lanieri L</searchLink>; eGenesis, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Getchell+K%22">Getchell K</searchLink>; eGenesis, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Low+SC%22">Low SC</searchLink>; eGenesis, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Olthoff+KM%22">Olthoff KM</searchLink>; Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Furth+EE%22">Furth EE</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Keating+BJ%22">Keating BJ</searchLink>; Division of Transplantation, Department of Surgery, New York University Langone Health, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Friend+P%22">Friend P</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, The Churchill Hospital, Oxford, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Poncz+M%22">Poncz M</searchLink>; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Shaked+A%22">Shaked A</searchLink>; Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Abrams+CS%22">Abrams CS</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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  Data: <searchLink fieldCode="JN" term="%227802877%22">The Journal of clinical investigation</searchLink> [J Clin Invest] 2026 Mar 10; Vol. 136 (9). <i>Date of Electronic Publication: </i>2026 Mar 10 (<i>Print Publication: </i>2026).
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