Methods and operational framework of GALFLU: Individually randomized pragmatic controlled trial of high- versus standard-dose influenza vaccination in older adults.
Saved in:
| Title: | Methods and operational framework of GALFLU: Individually randomized pragmatic controlled trial of high- versus standard-dose influenza vaccination in older adults. |
|---|---|
| Authors: | Mallah N; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBER-ESP), Madrid, Spain; Department of Preventive Medicine and Institute of Psychology (IPISUS), University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain., Pardo-Seco J; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), and INCIFOR, Universidade de Santiago de Compostela (USC), 15706 Santiago de Compostela, Galicia, Spain., Rodriguez-Tenreiro-Sánchez C; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., Giné-Vázquez I; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., Mirás-Carballal S; Galician Center for Disease Control and Prevention (CEGACE). Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain., Piñeiro-Sotelo M; Galician Center for Disease Control and Prevention (CEGACE). Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain., Cribeiro-González M; Department of Communicable Diseases, Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain., Conde-Pájaro M; Dirección Xeral de Recursos Económicos, Servizo Galego de Saúde, Xunta de Galicia, Galicia, Spain.Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain., González-Pérez JM; Subdirección de Sistemas y Tecnologías de la Información, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain., Razzini JL; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain., Rivero-Calle I; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago (SERGAS) and University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain., Dacosta-Urbieta AI; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago (SERGAS) and University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain., Harris RC; Sanofi Vaccines, Singapore., Loiacono MM; Department of Epidemiology, University of Delaware, Newark, DE, USA., van Aalst R; Sanofi Vaccines, Morristown, NJ, USA., Farre JM; Sanofi Vaccines, Barcelona, Spain., Dufournet M; Sanofi Vaccines, Lyon, France., Johansen ND; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Modin D; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark., Biering-Sørensen T; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Herlev, Denmark., Duran-Parrondo C; Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain., Martinón-Torres F; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago (SERGAS) and University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain. Electronic address: federico.martinon.torres@sergas.es. |
| Corporate Authors: | GALFLU trial team |
| Source: | Vaccine [Vaccine] 2026 Apr 19; Vol. 79, pp. 128435. Date of Electronic Publication: 2026 Mar 09. |
| Publication Type: | Journal Article; Pragmatic Clinical Trial; Randomized Controlled Trial |
| Journal Info: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41806760 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Methods and operational framework of GALFLU: Individually randomized pragmatic controlled trial of high- versus standard-dose influenza vaccination in older adults. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Mallah+N%22">Mallah N</searchLink>; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBER-ESP), Madrid, Spain; Department of Preventive Medicine and Institute of Psychology (IPISUS), University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Pardo-Seco+J%22">Pardo-Seco J</searchLink>; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; GenPoB Research Group, Instituto de Investigación Sanitaria (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), and INCIFOR, Universidade de Santiago de Compostela (USC), 15706 Santiago de Compostela, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Tenreiro-Sánchez+C%22">Rodriguez-Tenreiro-Sánchez C</searchLink>; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Giné-Vázquez+I%22">Giné-Vázquez I</searchLink>; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Mirás-Carballal+S%22">Mirás-Carballal S</searchLink>; Galician Center for Disease Control and Prevention (CEGACE). Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Piñeiro-Sotelo+M%22">Piñeiro-Sotelo M</searchLink>; Galician Center for Disease Control and Prevention (CEGACE). Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Cribeiro-González+M%22">Cribeiro-González M</searchLink>; Department of Communicable Diseases, Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Conde-Pájaro+M%22">Conde-Pájaro M</searchLink>; Dirección Xeral de Recursos Económicos, Servizo Galego de Saúde, Xunta de Galicia, Galicia, Spain.Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22González-Pérez+JM%22">González-Pérez JM</searchLink>; Subdirección de Sistemas y Tecnologías de la Información, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Razzini+JL%22">Razzini JL</searchLink>; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rivero-Calle+I%22">Rivero-Calle I</searchLink>; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago (SERGAS) and University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Dacosta-Urbieta+AI%22">Dacosta-Urbieta AI</searchLink>; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago (SERGAS) and University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Harris+RC%22">Harris RC</searchLink>; Sanofi Vaccines, Singapore.<br /><searchLink fieldCode="AU" term="%22Loiacono+MM%22">Loiacono MM</searchLink>; Department of Epidemiology, University of Delaware, Newark, DE, USA.<br /><searchLink fieldCode="AU" term="%22van+Aalst+R%22">van Aalst R</searchLink>; Sanofi Vaccines, Morristown, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Farre+JM%22">Farre JM</searchLink>; Sanofi Vaccines, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Dufournet+M%22">Dufournet M</searchLink>; Sanofi Vaccines, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Johansen+ND%22">Johansen ND</searchLink>; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Modin+D%22">Modin D</searchLink>; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Biering-Sørensen+T%22">Biering-Sørensen T</searchLink>; Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark; Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Herlev, Denmark.<br /><searchLink fieldCode="AU" term="%22Duran-Parrondo+C%22">Duran-Parrondo C</searchLink>; Dirección Xeral de Saúde Pública, Consellería de Sanidade, Xunta de Galicia, Galicia, Spain.<br /><searchLink fieldCode="AU" term="%22Martinón-Torres+F%22">Martinón-Torres F</searchLink>; Genetics, Vaccines and Infectious Diseases Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Galicia, Spain; WHO Collaborating Centre for Vaccine Safety, Santiago de Compostela, Galicia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Translational Pediatrics and Infectious Diseases, Hospital Clínico Universitario de Santiago (SERGAS) and University of Santiago de Compostela (USC), Santiago de Compostela, Galicia, Spain. Electronic address: federico.martinon.torres@sergas.es. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22GALFLU+trial+team%22">GALFLU trial team</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228406899%22">Vaccine</searchLink> [Vaccine] 2026 Apr 19; Vol. 79, pp. 128435. <i>Date of Electronic Publication: </i>2026 Mar 09. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Pragmatic Clinical Trial; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8406899 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2518 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220264410X%22">0264410X </searchLink><i>NLM ISO Abbreviation: </i>Vaccine <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41806760 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.vaccine.2026.128435 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 128435 Titles: – TitleFull: Methods and operational framework of GALFLU: Individually randomized pragmatic controlled trial of high- versus standard-dose influenza vaccination in older adults. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mallah N – PersonEntity: Name: NameFull: Pardo-Seco J – PersonEntity: Name: NameFull: Rodriguez-Tenreiro-Sánchez C – PersonEntity: Name: NameFull: Giné-Vázquez I – PersonEntity: Name: NameFull: Mirás-Carballal S – PersonEntity: Name: NameFull: Piñeiro-Sotelo M – PersonEntity: Name: NameFull: Cribeiro-González M – PersonEntity: Name: NameFull: Conde-Pájaro M – PersonEntity: Name: NameFull: González-Pérez JM – PersonEntity: Name: NameFull: Razzini JL – PersonEntity: Name: NameFull: Rivero-Calle I – PersonEntity: Name: NameFull: Dacosta-Urbieta AI – PersonEntity: Name: NameFull: Harris RC – PersonEntity: Name: NameFull: Loiacono MM – PersonEntity: Name: NameFull: van Aalst R – PersonEntity: Name: NameFull: Farre JM – PersonEntity: Name: NameFull: Dufournet M – PersonEntity: Name: NameFull: Johansen ND – PersonEntity: Name: NameFull: Modin D – PersonEntity: Name: NameFull: Biering-Sørensen T – PersonEntity: Name: NameFull: Duran-Parrondo C – PersonEntity: Name: NameFull: Martinón-Torres F IsPartOfRelationships: – BibEntity: Dates: – D: 19 M: 04 Text: 2026 Apr 19 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1873-2518 Numbering: – Type: volume Value: 79 Titles: – TitleFull: Vaccine Type: main |
| ResultId | 1 |
