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Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery.

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Title: Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery.
Authors: Li J; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Wang X; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Ding Y; Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou 221004, China., Qin F; Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou 221004, China., de Lima STS; Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA; Laboratório Central de Saúde Pública do Ceará, Fortaleza, Brazil; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil., Papamichail L; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands., Schraauwen R; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Forato J; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil., Claro IM; Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA., Hua X; Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA., Simões Mello LM; Laboratório Central de Saúde Pública do Ceará, Fortaleza, Brazil., Offermans DM; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Verstegen MMA; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands., Boter M; Department of Viroscience, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Peppelenbosch MP; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Barbiero A; Experimental and Clinical Medicine Department, University of Florence, Florence, Italy., Pagani E; Laboratory of Microbiology and Virology, Provincial Hospital of Bolzano (SABES-ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Bolzano, Italy., Janssen HLA; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, ON, Canada., Telmos Silva JA; Laboratório do Hospital da Mulher de Fortaleza, Fortaleza, Brazil., Dos Santos MNN; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, Brazil., Pincinato EC; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, Brazil., Proenca-Modena JL; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil., Li P; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., Anas AA; Department of Medical Microbiology and Infectious Diseases, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; Department of Internal Medicine, Section of Infectious Diseases, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., van der Laan LJW; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands., Castilletti C; Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, Italy., Oude Munnink BB; Department of Viroscience, Erasmus MC-University Medical Center, Rotterdam, the Netherlands., de Souza WM; Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA. Electronic address: wmdesouza@uky.edu., Wang W; Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: wenshi.wang@xzhmu.edu.cn., Pan Q; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands. Electronic address: q.pan@erasmusmc.nl.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Mar 17; Vol. 7 (3), pp. 102646. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
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  Data: Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery.
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  Data: <searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ding+Y%22">Ding Y</searchLink>; Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou 221004, China.<br /><searchLink fieldCode="AU" term="%22Qin+F%22">Qin F</searchLink>; Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou 221004, China.<br /><searchLink fieldCode="AU" term="%22de+Lima+STS%22">de Lima STS</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA; Laboratório Central de Saúde Pública do Ceará, Fortaleza, Brazil; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Papamichail+L%22">Papamichail L</searchLink>; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schraauwen+R%22">Schraauwen R</searchLink>; Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Forato+J%22">Forato J</searchLink>; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Claro+IM%22">Claro IM</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Hua+X%22">Hua X</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA.<br /><searchLink fieldCode="AU" term="%22Simões+Mello+LM%22">Simões Mello LM</searchLink>; Laboratório Central de Saúde Pública do Ceará, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Offermans+DM%22">Offermans DM</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verstegen+MMA%22">Verstegen MMA</searchLink>; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Boter+M%22">Boter M</searchLink>; Department of Viroscience, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Peppelenbosch+MP%22">Peppelenbosch MP</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Barbiero+A%22">Barbiero A</searchLink>; Experimental and Clinical Medicine Department, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Pagani+E%22">Pagani E</searchLink>; Laboratory of Microbiology and Virology, Provincial Hospital of Bolzano (SABES-ASDAA), Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität, Bolzano, Italy.<br /><searchLink fieldCode="AU" term="%22Janssen+HLA%22">Janssen HLA</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; Toronto Centre for Liver Disease, Toronto General Hospital, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Telmos+Silva+JA%22">Telmos Silva JA</searchLink>; Laboratório do Hospital da Mulher de Fortaleza, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+MNN%22">Dos Santos MNN</searchLink>; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Pincinato+EC%22">Pincinato EC</searchLink>; Department of Clinical Pathology, School of Medical Sciences, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Proenca-Modena+JL%22">Proenca-Modena JL</searchLink>; Laboratory of Emerging Viruses, Department of Genetics, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Li+P%22">Li P</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Anas+AA%22">Anas AA</searchLink>; Department of Medical Microbiology and Infectious Diseases, Erasmus MC-University Medical Center, Rotterdam, the Netherlands; Department of Internal Medicine, Section of Infectious Diseases, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Laan+LJW%22">van der Laan LJW</searchLink>; Department of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Castilletti+C%22">Castilletti C</searchLink>; Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Oude+Munnink+BB%22">Oude Munnink BB</searchLink>; Department of Viroscience, Erasmus MC-University Medical Center, Rotterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Souza+WM%22">de Souza WM</searchLink>; Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA. Electronic address: wmdesouza@uky.edu.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: wenshi.wang@xzhmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Pan+Q%22">Pan Q</searchLink>; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, the Netherlands. Electronic address: q.pan@erasmusmc.nl.
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  Data: <searchLink fieldCode="JN" term="%22101766894%22">Cell reports. Medicine</searchLink> [Cell Rep Med] 2026 Mar 17; Vol. 7 (3), pp. 102646. <i>Date of Electronic Publication: </i>2026 Mar 09.
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