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Higher polygenic risk for cardiovascular disease is associated with lower cerebral blood flow in youth with bipolar disorder.

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Title: Higher polygenic risk for cardiovascular disease is associated with lower cerebral blood flow in youth with bipolar disorder.
Authors: Kulkarni NP; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada., Zai CC; Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada., Kennedy KG; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada., Mio M; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada., Young LT; Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada., MacIntosh BJ; Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Sandra E Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada., Goldstein BI; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada. Electronic address: benjamin.goldstein@camh.ca.
Source: Neurobiology of disease [Neurobiol Dis] 2026 Apr; Vol. 221, pp. 107347. Date of Electronic Publication: 2026 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE
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  Data: Higher polygenic risk for cardiovascular disease is associated with lower cerebral blood flow in youth with bipolar disorder.
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  Data: <searchLink fieldCode="AU" term="%22Kulkarni+NP%22">Kulkarni NP</searchLink>; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Zai+CC%22">Zai CC</searchLink>; Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Kennedy+KG%22">Kennedy KG</searchLink>; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Mio+M%22">Mio M</searchLink>; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Young+LT%22">Young LT</searchLink>; Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22MacIntosh+BJ%22">MacIntosh BJ</searchLink>; Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Sandra E Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Goldstein+BI%22">Goldstein BI</searchLink>; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada. Electronic address: benjamin.goldstein@camh.ca.
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  Data: <searchLink fieldCode="JN" term="%229500169%22">Neurobiology of disease</searchLink> [Neurobiol Dis] 2026 Apr; Vol. 221, pp. 107347. <i>Date of Electronic Publication: </i>2026 Mar 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9500169 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-953X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209699961%22">09699961 </searchLink><i>NLM ISO Abbreviation: </i>Neurobiol Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.nbd.2026.107347
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      – TitleFull: Higher polygenic risk for cardiovascular disease is associated with lower cerebral blood flow in youth with bipolar disorder.
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              Text: 2026 Apr
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