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Hetero-oligomerization drives structural plasticity of eukaryotic peroxiredoxins.

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Title: Hetero-oligomerization drives structural plasticity of eukaryotic peroxiredoxins.
Authors: Zimmermann J; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany., Lang L; Faculty of Chemistry, Comparative Biochemistry, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany., Malo Pueyo J; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.; Brussels Center for Redox Biology, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium., Riedel M; Faculty of Chemistry, Comparative Biochemistry, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany., Wahni K; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.; Brussels Center for Redox Biology, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium., Stobbe D; Redox Metabolism, Institute for Biochemistry, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Leiskau L; Faculty of Chemistry, Comparative Biochemistry, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany., Aref E; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany., Lux C; Computational Systems Biology, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany., Janvier S; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium., Vertommen D; De Duve Institute, MASSPROT Platform, UCLouvain, Brussels, Belgium., Lenhard S; Cell Biology, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany., Hannemann F; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany., Thangamuragan S; Center for Bioinformatics, Saarland University, Saarbrücken, Germany., Castro H; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal., Helms V; Center for Bioinformatics, Saarland University, Saarbrücken, Germany., Tomas AM; i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal., Herrmann JM; Cell Biology, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany., Salvador A; CNC-UC-Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CiBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; Coimbra Chemistry Center-Institute of Molecular Sciences (CQC-IMS), University of Coimbra, Coimbra, Portugal.; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal., Mühlhaus T; Computational Systems Biology, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany., Riemer J; Redox Metabolism, Institute for Biochemistry, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Messens J; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium. joris.messens@vub.be.; Brussels Center for Redox Biology, Brussels, Belgium. joris.messens@vub.be.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium. joris.messens@vub.be., Deponte M; Faculty of Chemistry, Comparative Biochemistry, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany. deponte@rptu.de., Morgan B; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany. bruce.morgan@uni-saarland.de.
Source: Nature chemical biology [Nat Chem Biol] 2026 Apr; Vol. 22 (4), pp. 580-592. Date of Electronic Publication: 2026 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Zimmermann+J%22">Zimmermann J</searchLink>; Institute of Biochemistry, Center for Human and Molecular Biology (ZHMB), Saarland University, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Lang+L%22">Lang L</searchLink>; Faculty of Chemistry, Comparative Biochemistry, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany.<br /><searchLink fieldCode="AU" term="%22Malo+Pueyo+J%22">Malo Pueyo J</searchLink>; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.; Brussels Center for Redox Biology, Brussels, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Riedel+M%22">Riedel M</searchLink>; Faculty of Chemistry, Comparative Biochemistry, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany.<br /><searchLink fieldCode="AU" term="%22Wahni+K%22">Wahni K</searchLink>; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.; 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i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.<br /><searchLink fieldCode="AU" term="%22Herrmann+JM%22">Herrmann JM</searchLink>; Cell Biology, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany.<br /><searchLink fieldCode="AU" term="%22Salvador+A%22">Salvador A</searchLink>; CNC-UC-Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.; CiBB-Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.; Coimbra Chemistry Center-Institute of Molecular Sciences (CQC-IMS), University of Coimbra, Coimbra, Portugal.; Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Mühlhaus+T%22">Mühlhaus T</searchLink>; Computational Systems Biology, University of Kaiserslautern-Landau (RPTU), Kaiserslautern, Germany.<br /><searchLink fieldCode="AU" term="%22Riemer+J%22">Riemer J</searchLink>; 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