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Integrating real-world data with gold-standard longitudinal clinical and genomic data to advance precision medicine for the Alzheimer's Disease Research Center Program and beyond: a proof-of-concept data platform.

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Title: Integrating real-world data with gold-standard longitudinal clinical and genomic data to advance precision medicine for the Alzheimer's Disease Research Center Program and beyond: a proof-of-concept data platform.
Authors: Biber S; Department of Neurology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.; Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA., Culhane JE; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA., Prado MG; Department of Family Medicine, University of Washington, Seattle, Washington, USA., Mathew S; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA., Burrola-Mendez Y; Department of Family Medicine, University of Washington, Seattle, Washington, USA., West II; Department of Family Medicine, University of Washington, Seattle, Washington, USA., Van Heiden S; Indiana Alzheimer's Disease Research Center, IU Health Neuroscience Center, Indianapolis, Indiana, USA., Phuong J; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA., Allimatti S; National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, USA., Lane LG; Department of Epidemiology, University of Washington, Seattle, Washington, USA.; National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA., Moulder KL; Department of Neurology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, St. Louis, Missouri, USA., Hale BK; Department of Neurology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA., Kuzma A; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Wang LS; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Gao S; Indiana Alzheimer's Disease Research Center, IU Health Neuroscience Center, Indianapolis, Indiana, USA., Lai A; Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA., Natarajan K; Columbia University Irving Medical Center, New York, New York, USA., Wang S; Indiana Alzheimer's Disease Research Center, IU Health Neuroscience Center, Indianapolis, Indiana, USA., Morris JC; Department of Neurology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, St. Louis, Missouri, USA., Noble JM; Columbia University Irving Medical Center, New York, New York, USA., Mooney SD; Center for Information Technology, National Institutes of Health, Bethesda, Maryland, USA., Kukull W; Department of Neurology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA., Saykin AJ; Indiana Alzheimer's Disease Research Center, IU Health Neuroscience Center, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA., Stephens KA; Department of Family Medicine, University of Washington, Seattle, Washington, USA.
Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Mar; Vol. 22 (3), pp. e71207.
Publication Type: Journal Article
Journal Info: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrating real-world data with gold-standard longitudinal clinical and genomic data to advance precision medicine for the Alzheimer's Disease Research Center Program and beyond: a proof-of-concept data platform.
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National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.<br /><searchLink fieldCode="AU" term="%22Moulder+KL%22">Moulder KL</searchLink>; Department of Neurology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Hale+BK%22">Hale BK</searchLink>; Department of Neurology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Kuzma+A%22">Kuzma A</searchLink>; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Wang+LS%22">Wang LS</searchLink>; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.<br /><searchLink fieldCode="AU" term="%22Gao+S%22">Gao S</searchLink>; Indiana Alzheimer's Disease Research Center, IU Health Neuroscience Center, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Lai+A%22">Lai A</searchLink>; Institute for Informatics, Data Science and Biostatistics, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Natarajan+K%22">Natarajan K</searchLink>; Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Indiana Alzheimer's Disease Research Center, IU Health Neuroscience Center, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Morris+JC%22">Morris JC</searchLink>; Department of Neurology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.; The Charles F. and Joanne Knight Alzheimer Disease Research Center, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Noble+JM%22">Noble JM</searchLink>; Columbia University Irving Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Mooney+SD%22">Mooney SD</searchLink>; Center for Information Technology, National Institutes of Health, Bethesda, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kukull+W%22">Kukull W</searchLink>; Department of Neurology, Washington University School of Medicine in St. Louis, Saint Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Saykin+AJ%22">Saykin AJ</searchLink>; Indiana Alzheimer's Disease Research Center, IU Health Neuroscience Center, Indianapolis, Indiana, USA.; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.<br /><searchLink fieldCode="AU" term="%22Stephens+KA%22">Stephens KA</searchLink>; Department of Family Medicine, University of Washington, Seattle, Washington, USA.
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