Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz-Jeghers syndrome.

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Title: Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz-Jeghers syndrome.
Authors: Yuan L; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Tong Q; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Xie K; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Li C; The School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Wang Z; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Hong A; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Tang L; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., You J; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Ouyang H; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Liu L; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Zhang W; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Li C; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Zhan M; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Jiang N; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Duan J; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Liu C; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Zhou J; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Wang H; Department of Medical Genetics, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Liu J; Department of Ultrasound, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Zhu G; The Affiliated Children's Hospital Of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Hunan Provincial Key Laboratory of Pediatric Orthopedics, Changsha, China.; Furong Laboratory, Changsha, China., Deng Y; The School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China., Zhao H; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.; The School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children's Hospital), Changsha, China.
Source: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2026 Jun; Vol. 82 (6), pp. 1377-1385. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 8211545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-4801 (Electronic) Linking ISSN: 02772116 NLM ISO Abbreviation: J Pediatr Gastroenterol Nutr Subsets: MEDLINE
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  Data: Distinct polyp recurrence timing and STK11 mutation status underlie clinical heterogeneity in pediatric Peutz-Jeghers syndrome.
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  Data: <searchLink fieldCode="AU" term="%22Yuan+L%22">Yuan L</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Tong+Q%22">Tong Q</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Xie+K%22">Xie K</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; The School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Hong+A%22">Hong A</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Tang+L%22">Tang L</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22You+J%22">You J</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Ouyang+H%22">Ouyang H</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Li+C%22">Li C</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhan+M%22">Zhan M</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Jiang+N%22">Jiang N</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Duan+J%22">Duan J</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhou+J%22">Zhou J</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Medical Genetics, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Ultrasound, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhu+G%22">Zhu G</searchLink>; The Affiliated Children's Hospital Of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Hunan Provincial Key Laboratory of Pediatric Orthopedics, Changsha, China.; Furong Laboratory, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Deng+Y%22">Deng Y</searchLink>; The School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children's Hospital), Changsha, China.; Pediatrics Research Institute of Hunan Province, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Department of Gastroenterology and Nutrition, the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.; The School of Pediatrics, Hengyang Medical School, University of South China (Hunan Children's Hospital), Changsha, China.
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  Data: <searchLink fieldCode="JN" term="%228211545%22">Journal of pediatric gastroenterology and nutrition</searchLink> [J Pediatr Gastroenterol Nutr] 2026 Jun; Vol. 82 (6), pp. 1377-1385. <i>Date of Electronic Publication: </i>2026 Mar 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley%22">Wiley </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8211545 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1536-4801 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202772116%22">02772116 </searchLink><i>NLM ISO Abbreviation: </i>J Pediatr Gastroenterol Nutr <i>Subsets: </i>MEDLINE
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        Value: 10.1002/jpn3.70376
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        Text: English
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              Text: 2026 Jun
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