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PAICS mediates DNA damage and cerebellar neuronal loss in C9orf72 amyotrophic lateral sclerosis.

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Title: PAICS mediates DNA damage and cerebellar neuronal loss in C9orf72 amyotrophic lateral sclerosis.
Authors: Singh J; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier Santé Biotechnologie, Laval, QC H7V 1B7, Canada., Lescouzères L; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier Santé Biotechnologie, Laval, QC H7V 1B7, Canada., Zaouter C; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier Santé Biotechnologie, Laval, QC H7V 1B7, Canada., Chaineau M; The Neuro's Early Drug Discovery Unit (EDDU) McGill University, Montreal, QC, Canada., Haghi G; The Neuro's Early Drug Discovery Unit (EDDU) McGill University, Montreal, QC, Canada., Durcan TM; The Neuro's Early Drug Discovery Unit (EDDU) McGill University, Montreal, QC, Canada., Patten SA; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier Santé Biotechnologie, Laval, QC H7V 1B7, Canada.; Département de Neurosciences, Université de Montréal, Montréal, QC H3C 3J7, Canada.
Source: Brain : a journal of neurology [Brain] 2026 Mar 11. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: PAICS mediates DNA damage and cerebellar neuronal loss in C9orf72 amyotrophic lateral sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Singh+J%22">Singh J</searchLink>; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier Santé Biotechnologie, Laval, QC H7V 1B7, Canada.<br /><searchLink fieldCode="AU" term="%22Lescouzères+L%22">Lescouzères L</searchLink>; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier Santé Biotechnologie, Laval, QC H7V 1B7, Canada.<br /><searchLink fieldCode="AU" term="%22Zaouter+C%22">Zaouter C</searchLink>; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier Santé Biotechnologie, Laval, QC H7V 1B7, Canada.<br /><searchLink fieldCode="AU" term="%22Chaineau+M%22">Chaineau M</searchLink>; The Neuro's Early Drug Discovery Unit (EDDU) McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Haghi+G%22">Haghi G</searchLink>; The Neuro's Early Drug Discovery Unit (EDDU) McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Durcan+TM%22">Durcan TM</searchLink>; The Neuro's Early Drug Discovery Unit (EDDU) McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Patten+SA%22">Patten SA</searchLink>; Institut National de la Recherche Scientifique (INRS), Centre Armand Frappier Santé Biotechnologie, Laval, QC H7V 1B7, Canada.; Département de Neurosciences, Université de Montréal, Montréal, QC H3C 3J7, Canada.
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        Value: 10.1093/brain/awag092
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      – TitleFull: PAICS mediates DNA damage and cerebellar neuronal loss in C9orf72 amyotrophic lateral sclerosis.
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              Text: 2026 Mar 11
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              Y: 2026
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