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Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model.

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Title: Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model.
Authors: Reitsma TH; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands., Savarese G; Department of Clinical Science and Education, Södersjukhuset; Karolinska Institute, Stockholm, Sweden., Kuźma Ł; Department of Invasive Cardiology, Medical University of Białystok, Białystok, Poland.; Department of Cardiac Surgery and Transplantology, National Medical Institute of the Ministry of Interior, Warsaw, Poland.; Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK., Deo SV; 6Surgical Services, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.; Case School of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; School of Health and Wellbeing, University of Glasgow, UK., Pennells L; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK., Hageman SHJ; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands., Holtrop J; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands., Benson L; Department of Clinical Science and Education, Södersjukhuset; Karolinska Institute, Stockholm, Sweden., Conrad N; Nuffield Department of Women's and Reproductive Health, University of Oxford, UK.; Department of Cardiovascular Sciences, KU Leuven, Belgium., Lund LH; 14Karolinska Institutet, Department of Medicine and KArolinska University Hospital, Department of Cardiology, Sweden., Kurasz A; Department of Invasive Cardiology, Medical University of Białystok, Białystok, Poland., Kaptoge S; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK., Keene SJ; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK., Chilala C; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK., Pitt M; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK., Fletcher RA; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.; Health Data Research UK, London, UK.; The George Institute for Global Health, University of New South Wales, Sydney, Australia., Khunti K; Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK., Piepoli M; Department of Biomedical Science for Health, University of Milan, Italy.; Clinical University Cardiology, IRCCS Policlinico San Donato, Milan, Italy., Rossello X; Hospital Universitario Son Espases, Health Research Institute of the Balearic Islands, Universitat Illes Balears, Palma de Mallorca, Spain., Lees JS; School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK., Kavousi M; Department of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., McEvoy JW; University of Galway School of Medicine and National Institute for Prevention and Cardiovascular Health, Galway, Ireland., Wood AM; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK., de Boer RA; Cardiovascular Institute, Erasmus MC, Department of Cardiology, Thorax Center, Rotterdam, The Netherlands., Andersson C; Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark.; Center for Advanced Heart Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Visseren FLJ; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands., Koudstaal S; Cardiovascular Institute, Erasmus MC, Department of Cardiology, Thorax Center, Rotterdam, The Netherlands., Di Angelantonio E; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Health Data Science Research Centre, Human Technopole, Milan, Italy., Dorresteijn JAN; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Corporate Authors: ESC Cardiovascular Risk Collaboration and the CVD-COVID-UK/COVID-IMPACT Consortium
Source: European heart journal [Eur Heart J] 2026 Mar 11. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8006263 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-9645 (Electronic) Linking ISSN: 0195668X NLM ISO Abbreviation: Eur Heart J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model.
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  Data: <searchLink fieldCode="AU" term="%22Reitsma+TH%22">Reitsma TH</searchLink>; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Savarese+G%22">Savarese G</searchLink>; Department of Clinical Science and Education, Södersjukhuset; Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Kuźma+Ł%22">Kuźma Ł</searchLink>; Department of Invasive Cardiology, Medical University of Białystok, Białystok, Poland.; Department of Cardiac Surgery and Transplantology, National Medical Institute of the Ministry of Interior, Warsaw, Poland.; Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Deo+SV%22">Deo SV</searchLink>; 6Surgical Services, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.; Case School of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA.; School of Health and Wellbeing, University of Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Pennells+L%22">Pennells L</searchLink>; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Hageman+SHJ%22">Hageman SHJ</searchLink>; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Holtrop+J%22">Holtrop J</searchLink>; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Benson+L%22">Benson L</searchLink>; Department of Clinical Science and Education, Södersjukhuset; Karolinska Institute, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Conrad+N%22">Conrad N</searchLink>; Nuffield Department of Women's and Reproductive Health, University of Oxford, UK.; Department of Cardiovascular Sciences, KU Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Lund+LH%22">Lund LH</searchLink>; 14Karolinska Institutet, Department of Medicine and KArolinska University Hospital, Department of Cardiology, Sweden.<br /><searchLink fieldCode="AU" term="%22Kurasz+A%22">Kurasz A</searchLink>; Department of Invasive Cardiology, Medical University of Białystok, Białystok, Poland.<br /><searchLink fieldCode="AU" term="%22Kaptoge+S%22">Kaptoge S</searchLink>; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.<br /><searchLink fieldCode="AU" term="%22Keene+SJ%22">Keene SJ</searchLink>; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.<br /><searchLink fieldCode="AU" term="%22Chilala+C%22">Chilala C</searchLink>; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.<br /><searchLink fieldCode="AU" term="%22Pitt+M%22">Pitt M</searchLink>; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fletcher+RA%22">Fletcher RA</searchLink>; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.; Health Data Research UK, London, UK.; The George Institute for Global Health, University of New South Wales, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Khunti+K%22">Khunti K</searchLink>; Diabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Piepoli+M%22">Piepoli M</searchLink>; Department of Biomedical Science for Health, University of Milan, Italy.; Clinical University Cardiology, IRCCS Policlinico San Donato, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Rossello+X%22">Rossello X</searchLink>; Hospital Universitario Son Espases, Health Research Institute of the Balearic Islands, Universitat Illes Balears, Palma de Mallorca, Spain.<br /><searchLink fieldCode="AU" term="%22Lees+JS%22">Lees JS</searchLink>; School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Kavousi+M%22">Kavousi M</searchLink>; Department of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22McEvoy+JW%22">McEvoy JW</searchLink>; University of Galway School of Medicine and National Institute for Prevention and Cardiovascular Health, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Wood+AM%22">Wood AM</searchLink>; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK.<br /><searchLink fieldCode="AU" term="%22de+Boer+RA%22">de Boer RA</searchLink>; Cardiovascular Institute, Erasmus MC, Department of Cardiology, Thorax Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Andersson+C%22">Andersson C</searchLink>; Department of Cardiology, Copenhagen University Hospital Herlev and Gentofte, Herlev, Denmark.; Center for Advanced Heart Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Visseren+FLJ%22">Visseren FLJ</searchLink>; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Koudstaal+S%22">Koudstaal S</searchLink>; Cardiovascular Institute, Erasmus MC, Department of Cardiology, Thorax Center, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Di+Angelantonio+E%22">Di Angelantonio E</searchLink>; 9British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Papworth Road, Cambridge Biomedical Campus, Cambridge, UK.; Victor Phillip Dahdaleh Heart and Lung Research Institute, University of Cambridge, Cambridge  UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Health Data Science Research Centre, Human Technopole, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Dorresteijn+JAN%22">Dorresteijn JAN</searchLink>; Department of Vascular Medicine and Endocrinology, University Medical Centre Utrecht, Utrecht, The Netherlands.
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