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Precision Diagnosis in APOL1 Kidney Disease With the p.N264K M1 Protective Variant.

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Title: Precision Diagnosis in APOL1 Kidney Disease With the p.N264K M1 Protective Variant.
Authors: Martinelli E; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Ke J; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Khan A; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Wongboonsin J; Division of Pediatric Nephrology, Boston Children's Hospital, Boston, Massachusetts.; Renal Division, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Division of Nephrology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Bumrungrad Genomic Medicine Institute and Department of Medicine, Bumrungrad International Hospital, Bangkok, Thailand., Vanderwall DR; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts., Lim TY; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Unit of Genomic Variability and Complex Diseases, Department of Medical Sciences, University of Turin, Turin, Italy., Santoriello D; The Renal Pathology Laboratory of the Department of Pathology and Cell Biology, Columbia University, New York, New York., Gupta Y; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany., McNulty MT; Division of Pediatric Nephrology, Boston Children's Hospital, Boston, Massachusetts.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge., Koyama S; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston., Puntambekar S; Division of Pediatric Nephrology, Boston Children's Hospital, Boston, Massachusetts., Bomback AS; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Canetta P; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Kretzler M; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor., Montini G; Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Morello W; Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy., Maggiore U; UO Nefrologia, Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy., Fiaccadori E; UO Nefrologia, Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy., Gesualdo L; Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J) Nephrology, Dialysis and Transplantation Unit, University of Bari Aldo Moro, Bari, Italy., Ghiggeri GM; Nephrology, Dialysis, and Transplantation, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Oliveira EA; Unidade de Nefrologia Pediátrica, Departamento de Pediatria, Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Simoes E Silva AC; Unidade de Nefrologia Pediátrica, Departamento de Pediatria, Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Bendapudi PK; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts.; Division of Hematology and Blood Transfusion Service, Massachusetts General Hospital, Boston.; Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Motelow J; Division of Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Medical Center, New York, New York., Garcia CK; Medicine/Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, New York, New York.; Precision Medicine Initiative and the Center for Precision Medicine and Genomics, Columbia University, New York, New York., Paul DS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Goldstein DB; Actio Biosciences Inc, San Diego, California., Friedman DJ; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts.; Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Radhakrishnan J; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Lin F; Division of Pediatric Nephrology, Department of Pediatrics, Columbia University, New York, New York., Mohan S; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Appel GB; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Saleem MA; Bristol Renal, University of Bristol, and Bristol Royal Children's Hospital, Bristol, United Kingdom., Natarajan P; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston., Hildebrandt F; Division of Pediatric Nephrology, Boston Children's Hospital, Boston, Massachusetts., Westland R; Department of Pediatric Nephrology, Amsterdam UMC - Emma Children's Hospital, location University of Amsterdam, Amsterdam, the Netherlands., D'Agati VD; The Renal Pathology Laboratory of the Department of Pathology and Cell Biology, Columbia University, New York, New York., Gbadegesin R; Division of Nephrology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina., Gharavi AG; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Pollak MR; Harvard Medical School, Boston, Massachusetts.; Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts., Kiryluk K; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York., Sampson MG; Division of Pediatric Nephrology, Boston Children's Hospital, Boston, Massachusetts.; Division of Nephrology, Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts.; Program in Medical and Population Genetics, Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge.; Department of Pediatrics and Medicine, Harvard Medical School, Boston, Massachusetts., Sanna-Cherchi S; Division of Nephrology, Department of Medicine, Columbia University Irving Medical Center, New York, New York.
Corporate Authors: Columbia Genomics Consortium
Source: JAMA network open [JAMA Netw Open] 2026 Mar 02; Vol. 9 (3), pp. e261452. Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
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