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FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor Therapy.

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Title: FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor Therapy.
Authors: Gracilla DE; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Menon S; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Breese MR; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California., Lin YP; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California., Dela Cruz FS; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Feinberg TY; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., de Stanchina E; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Galic AF; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Allegakoen H; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California., Perati SR; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California., Everin N; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Vizconde T; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York., Wen NJ; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Heslin A; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California., Somwar R; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Ladanyi M; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York., Horlbeck M; Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts., Weissman JS; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California., Sweet-Cordero EA; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California., Bivona TG; Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California.; Chan Zuckerberg Biohub, San Francisco, California., Tulpule A; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
Source: Cancer research [Cancer Res] 2026 Jun 01; Vol. 86 (11), pp. 2660-2677.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: FET Fusion Oncoproteins Disrupt Physiologic DNA Repair and Create a Targetable Opportunity for ATR Inhibitor Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Gracilla+DE%22">Gracilla DE</searchLink>; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Menon+S%22">Menon S</searchLink>; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Breese+MR%22">Breese MR</searchLink>; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Lin+YP%22">Lin YP</searchLink>; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Dela+Cruz+FS%22">Dela Cruz FS</searchLink>; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Feinberg+TY%22">Feinberg TY</searchLink>; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22de+Stanchina+E%22">de Stanchina E</searchLink>; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Galic+AF%22">Galic AF</searchLink>; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Allegakoen+H%22">Allegakoen H</searchLink>; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Perati+SR%22">Perati SR</searchLink>; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Everin+N%22">Everin N</searchLink>; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Vizconde+T%22">Vizconde T</searchLink>; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Wen+NJ%22">Wen NJ</searchLink>; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Heslin+A%22">Heslin A</searchLink>; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Somwar+R%22">Somwar R</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Ladanyi+M%22">Ladanyi M</searchLink>; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.<br /><searchLink fieldCode="AU" term="%22Horlbeck+M%22">Horlbeck M</searchLink>; Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Weissman+JS%22">Weissman JS</searchLink>; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Sweet-Cordero+EA%22">Sweet-Cordero EA</searchLink>; Division of Pediatric Oncology, University of California, San Francisco, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Bivona+TG%22">Bivona TG</searchLink>; Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California.; Chan Zuckerberg Biohub, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Tulpule+A%22">Tulpule A</searchLink>; Tow Center for Developmental Oncology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.
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