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Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications.

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Title: Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications.
Authors: Asiimwe R; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Knott B; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Greene ME; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Wright ED; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Bell M; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Epstein D; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Yates SD; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Gonzalez MV; Center for Cytokine Storm Treatment & Laboratory, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Fry S; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Boydston Procópio E; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Clevenger S; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Locke JE; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Brocato BE; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Burgan CM; Department of Radiology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Burney R; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Arora N; Department of Pediatrics, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Duncan VE; Department of Pathology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Richter HE; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Gunn D; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Freud AG; Department of Pathology, Ohio State University, Columbus, OH 43210, USA., Little SC; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA., Porrett PM; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Mar 11; Vol. 18 (840), pp. eadp2196. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications.
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  Data: <searchLink fieldCode="AU" term="%22Asiimwe+R%22">Asiimwe R</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Knott+B%22">Knott B</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Greene+ME%22">Greene ME</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Wright+ED%22">Wright ED</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Bell+M%22">Bell M</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Epstein+D%22">Epstein D</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Yates+SD%22">Yates SD</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Gonzalez+MV%22">Gonzalez MV</searchLink>; Center for Cytokine Storm Treatment & Laboratory, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Fry+S%22">Fry S</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Boydston+Procópio+E%22">Boydston Procópio E</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Clevenger+S%22">Clevenger S</searchLink>; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Locke+JE%22">Locke JE</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Brocato+BE%22">Brocato BE</searchLink>; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Burgan+CM%22">Burgan CM</searchLink>; Department of Radiology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Burney+R%22">Burney R</searchLink>; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Arora+N%22">Arora N</searchLink>; Department of Pediatrics, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Duncan+VE%22">Duncan VE</searchLink>; Department of Pathology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Richter+HE%22">Richter HE</searchLink>; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Gunn+D%22">Gunn D</searchLink>; Department of Obstetrics & Gynecology, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Freud+AG%22">Freud AG</searchLink>; Department of Pathology, Ohio State University, Columbus, OH 43210, USA.<br /><searchLink fieldCode="AU" term="%22Little+SC%22">Little SC</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.<br /><searchLink fieldCode="AU" term="%22Porrett+PM%22">Porrett PM</searchLink>; Department of Surgery, Marnix E. Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
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