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FYN/LCK kinase balance as a metabolic switch orchestrates progenitor-exhausted T-cell differentiation in hepatocellular carcinoma.

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Title: FYN/LCK kinase balance as a metabolic switch orchestrates progenitor-exhausted T-cell differentiation in hepatocellular carcinoma.
Authors: Wu J; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Jiang Z; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Li Q; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Cheng CS; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, P.R. China., Chan YT; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Yeerken R; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Chen J; Centre for Chinese Herbal Medicine Drug Development, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P.R. China., Lu P; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Feng Z; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Yuan H; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Xu L; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Meng Z; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, P.R. China., Feng Y; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China., Tan HY; Centre for Chinese Herbal Medicine Drug Development, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P.R. China., Wang N; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.
Source: Hepatology (Baltimore, Md.) [Hepatology] 2026 Mar 11. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
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  Data: FYN/LCK kinase balance as a metabolic switch orchestrates progenitor-exhausted T-cell differentiation in hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Jiang+Z%22">Jiang Z</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Cheng+CS%22">Cheng CS</searchLink>; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chan+YT%22">Chan YT</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Yeerken+R%22">Yeerken R</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Centre for Chinese Herbal Medicine Drug Development, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Lu+P%22">Lu P</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Feng+Z%22">Feng Z</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Yuan+H%22">Yuan H</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Xu+L%22">Xu L</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Meng+Z%22">Meng Z</searchLink>; Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, P.R. China.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Tan+HY%22">Tan HY</searchLink>; Centre for Chinese Herbal Medicine Drug Development, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, P.R. China.<br /><searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, P.R. China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer+Health%2C+Inc%22">Wolters Kluwer Health, Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8302946 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1527-3350 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202709139%22">02709139 </searchLink><i>NLM ISO Abbreviation: </i>Hepatology <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar 11
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