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Low- vs standard-dose regimens as induction for pediatric AML: a multicenter, randomized noninferiority trial.

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Title: Low- vs standard-dose regimens as induction for pediatric AML: a multicenter, randomized noninferiority trial.
Authors: Gao L; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.; Pediatric Hematology & Oncology Key Laboratory of Higher Education Institutions in Jiangsu Province, Suzhou, China., Zhai X; Department of Hematology and Oncology, Children's Hospital of Fudan University, Fudan University, Shanghai, China., Wang N; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China., Liao N; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China., Xiao P; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., Xu F; Department of Pediatrics, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China., Yang M; Department of Pediatrics, The Third Xiangya Hospital of Central South University, Central South University, Changsha, China., Xu X; Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China., An Q; Department of Hematology and Oncology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China., Luo J; Department of Hematology and Oncology, Kaifeng Children's Hospital, Kaifeng, China., Yang L; Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China., Yuan X; Department of Pediatric Hematology/Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China., He Y; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China., Zhuang Y; Department of Pediatrics, Qilu Hospital of Shandong University, Shandong University, Qingdao, China., Wang H; Department of Hematology and Oncology, Children's Hospital of Fudan University, Fudan University, Shanghai, China., Yang L; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China., Zhang W; Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Liu Y; Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China., Li J; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., He H; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., Wang Y; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., Cheng C; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN., Lu J; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China., Jiang H; Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Ju X; Department of Pediatrics, Qilu Hospital of Shandong University, Shandong University, Qingdao, China., Wang QF; China National Center for Bioinformation, Beijing, China.; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; School of Future Technology, University of Chinese Academy of Sciences, Beijing, China., Ribeiro RC; Division of Leukemia/Lymphoma, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN., Hu S; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.; Pediatric Hematology & Oncology Key Laboratory of Higher Education Institutions in Jiangsu Province, Suzhou, China.; Pediatric Hematology & Oncology Center of Jiangsu Province, Suzhou, China.
Source: Blood [Blood] 2026 Jul 02; Vol. 148 (1), pp. 71-83.
Publication Type: Equivalence Trial; Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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An: 41812214
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PubType: Academic Journal
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  Data: Low- vs standard-dose regimens as induction for pediatric AML: a multicenter, randomized noninferiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Gao+L%22">Gao L</searchLink>; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.; Pediatric Hematology & Oncology Key Laboratory of Higher Education Institutions in Jiangsu Province, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhai+X%22">Zhai X</searchLink>; Department of Hematology and Oncology, Children's Hospital of Fudan University, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Liao+N%22">Liao N</searchLink>; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Xiao+P%22">Xiao P</searchLink>; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Xu+F%22">Xu F</searchLink>; Department of Pediatrics, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; Department of Pediatrics, The Third Xiangya Hospital of Central South University, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22An+Q%22">An Q</searchLink>; Department of Hematology and Oncology, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, China.<br /><searchLink fieldCode="AU" term="%22Luo+J%22">Luo J</searchLink>; Department of Hematology and Oncology, Kaifeng Children's Hospital, Kaifeng, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.<br /><searchLink fieldCode="AU" term="%22Yuan+X%22">Yuan X</searchLink>; Department of Pediatric Hematology/Oncology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22He+Y%22">He Y</searchLink>; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Nanning, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+Y%22">Zhuang Y</searchLink>; Department of Pediatrics, Qilu Hospital of Shandong University, Shandong University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Hematology and Oncology, Children's Hospital of Fudan University, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China.<br /><searchLink fieldCode="AU" term="%22Zhang+W%22">Zhang W</searchLink>; Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22He+H%22">He H</searchLink>; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Cheng+C%22">Cheng C</searchLink>; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Lu+J%22">Lu J</searchLink>; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; Department of Hematology and Oncology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ju+X%22">Ju X</searchLink>; Department of Pediatrics, Qilu Hospital of Shandong University, Shandong University, Qingdao, China.<br /><searchLink fieldCode="AU" term="%22Wang+QF%22">Wang QF</searchLink>; China National Center for Bioinformation, Beijing, China.; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.; School of Future Technology, University of Chinese Academy of Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ribeiro+RC%22">Ribeiro RC</searchLink>; Division of Leukemia/Lymphoma, Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN.<br /><searchLink fieldCode="AU" term="%22Hu+S%22">Hu S</searchLink>; Department of Hematology and Oncology, Children's Hospital of Soochow University, Soochow University, Suzhou, China.; Pediatric Hematology & Oncology Key Laboratory of Higher Education Institutions in Jiangsu Province, Suzhou, China.; Pediatric Hematology & Oncology Center of Jiangsu Province, Suzhou, China.
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  Data: <searchLink fieldCode="JN" term="%227603509%22">Blood</searchLink> [Blood] 2026 Jul 02; Vol. 148 (1), pp. 71-83.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7603509 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-0020 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200064971%22">00064971 </searchLink><i>NLM ISO Abbreviation: </i>Blood <i>Subsets: </i>MEDLINE
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        Value: 10.1182/blood.2025030972
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              Text: 2026 Jul 02
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