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Immune evasive DNA donors and recombinases license kilobase-scale writing.

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Title: Immune evasive DNA donors and recombinases license kilobase-scale writing.
Authors: Tou CJ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. connorjtou@gmail.com.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. connorjtou@gmail.com.; Biological Engineering Program, Massachusetts Institute of Technology, Cambridge, MA, USA. connorjtou@gmail.com., Xie K; Full Circles Therapeutics, Cambridge, MA, USA., Ferreira da Silva J; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Kalailingam P; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Amar-Lewis E; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Rufino-Ramos D; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Sawyer W; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Eller ML; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Starzyk J; Full Circles Therapeutics, Cambridge, MA, USA., Majumdar I; Full Circles Therapeutics, Cambridge, MA, USA., Wang J; Full Circles Therapeutics, Cambridge, MA, USA., Lee D; Full Circles Therapeutics, Cambridge, MA, USA., Yang S; Department of Bioengineering, Northeastern University, Boston, MA, USA., Meis RJ; CELLSCRIPT, Madison, WI, USA.; Wisconsin Institute for Immune and Cell Therapy, Madison, WI, USA., Dahl GA; CELLSCRIPT, Madison, WI, USA.; Wisconsin Institute for Immune and Cell Therapy, Madison, WI, USA., Li J; Department of Bioengineering, Northeastern University, Boston, MA, USA., Shan R; Full Circles Therapeutics, Cambridge, MA, USA.; Stellate DNA, Cambridge, MA, USA.; Quintara Bioscience, Cambridge, MA, USA., Artzi N; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Musolino PL; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA., Wu H; Full Circles Therapeutics, Cambridge, MA, USA. howard.wu@fullcirclestx.com.; Stellate DNA, Cambridge, MA, USA. howard.wu@fullcirclestx.com., Kleinstiver BP; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.; Department of Pathology, Harvard Medical School, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.
Source: Nature [Nature] 2026 May; Vol. 653 (8114), pp. 576-586. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Immune evasive DNA donors and recombinases license kilobase-scale writing.
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  Data: <searchLink fieldCode="AU" term="%22Tou+CJ%22">Tou CJ</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. connorjtou@gmail.com.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. connorjtou@gmail.com.; Biological Engineering Program, Massachusetts Institute of Technology, Cambridge, MA, USA. connorjtou@gmail.com.<br /><searchLink fieldCode="AU" term="%22Xie+K%22">Xie K</searchLink>; Full Circles Therapeutics, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ferreira+da+Silva+J%22">Ferreira da Silva J</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kalailingam+P%22">Kalailingam P</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Amar-Lewis+E%22">Amar-Lewis E</searchLink>; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rufino-Ramos+D%22">Rufino-Ramos D</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sawyer+W%22">Sawyer W</searchLink>; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Eller+ML%22">Eller ML</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Starzyk+J%22">Starzyk J</searchLink>; Full Circles Therapeutics, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Majumdar+I%22">Majumdar I</searchLink>; Full Circles Therapeutics, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Full Circles Therapeutics, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+D%22">Lee D</searchLink>; Full Circles Therapeutics, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; Department of Bioengineering, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Meis+RJ%22">Meis RJ</searchLink>; CELLSCRIPT, Madison, WI, USA.; Wisconsin Institute for Immune and Cell Therapy, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Dahl+GA%22">Dahl GA</searchLink>; CELLSCRIPT, Madison, WI, USA.; Wisconsin Institute for Immune and Cell Therapy, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Bioengineering, Northeastern University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shan+R%22">Shan R</searchLink>; Full Circles Therapeutics, Cambridge, MA, USA.; Stellate DNA, Cambridge, MA, USA.; Quintara Bioscience, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Artzi+N%22">Artzi N</searchLink>; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Musolino+PL%22">Musolino PL</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Full Circles Therapeutics, Cambridge, MA, USA. howard.wu@fullcirclestx.com.; Stellate DNA, Cambridge, MA, USA. howard.wu@fullcirclestx.com.<br /><searchLink fieldCode="AU" term="%22Kleinstiver+BP%22">Kleinstiver BP</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.; Department of Pathology, Harvard Medical School, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.
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