Facile induction of immune tolerance by an interleukin-2-TGFβ surrogate agonist.

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Title: Facile induction of immune tolerance by an interleukin-2-TGFβ surrogate agonist.
Authors: Sun Q; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Barrett AK; Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA., Ogishi M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Lyu H; Diabetes Center, University of California, San Francisco, CA, USA.; Gladstone Institute-UCSF of Genomic Immunology, University of California, San Francisco, CA, USA., Jiang H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Liu H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Zhao Y; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Rodriguez GE; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA., Tao P; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Obenaus M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA., Householder KD; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA., Tang Q; Diabetes Center, University of California, San Francisco, CA, USA.; Gladstone Institute-UCSF of Genomic Immunology, University of California, San Francisco, CA, USA.; Department of Surgery, University of California, San Francisco, CA, USA., Lanz TV; Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA, USA.; Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, USA., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. kcgarcia@stanford.edu.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. kcgarcia@stanford.edu.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. kcgarcia@stanford.edu.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. kcgarcia@stanford.edu.
Source: Nature [Nature] 2026 May; Vol. 653 (8115), pp. 888-899. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4687
DOI:10.1038/s41586-026-10208-0