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B cell imprinting in children impairs antibodies to the haemagglutinin stalk.

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Title: B cell imprinting in children impairs antibodies to the haemagglutinin stalk.
Authors: Sun J; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Jo G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Troxell CA; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Fu Y; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Hoezl R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lv H; Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA., Abozeid HH; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.; Department of Poultry Diseases, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Teo QW; Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA., Pholcharee T; Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA., McGrath JJC; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Changrob S; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Nelson SA; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Yasuhara A; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Huang M; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Zheng NY; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Chervin JC; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Li L; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA., Fernández-Quintero ML; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Loeffler JR; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Rodriguez AJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Huang J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Swanson OM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Balmaseda A; Sustainable Sciences Institute, Managua, Nicaragua.; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministerio de Salud, Managua, Nicaragua., Kuan G; Sustainable Sciences Institute, Managua, Nicaragua.; Centro de Salud Sócrates Flores Vivas, Ministerio de Salud, Managua, Nicaragua., Campredon L; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kaitlynn Allen E; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Neumann G; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA., Wu NC; Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL, USA., Kawaoka Y; Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.; Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), University of Tokyo, Tokyo, Japan., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ignaz Semmelweis Institute, Interuniversity Institute for Infection Research, Medical University of Vienna, Vienna, Austria., Mejias A; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Ramilo O; Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA., Thomas PG; Department of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA., Gordon A; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Han J; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Wilson PC; Drukier Institute for Children's Health, Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA. pcw4001@med.cornell.edu.
Source: Nature [Nature] 2026 May; Vol. 653 (8114), pp. 528-537. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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