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Risk-adaptive therapy guided by dynamic ctDNA in nasopharyngeal carcinoma.

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Title: Risk-adaptive therapy guided by dynamic ctDNA in nasopharyngeal carcinoma.
Authors: Lv J; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Zheng DX; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Liang JH; Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, P. R. China., Zhang N; Department of Radiation Oncology, First People's Hospital of Foshan, Foshan, P. R. China., Ye ZL; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China., Xu XD; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Chua MLK; Duke NUS Medical School and Division of Radiation Oncology, National Cancer Centre, Singapore, Singapore., Zhang LL; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China., Du ZM; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China., Zhang ZC; Department of Molecular Diagnostics, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China., Li WF; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Tang LL; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Chen L; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Mao YP; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Guo R; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Chen YP; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Lin L; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Zhang Y; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Liu X; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Xu C; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Li ZX; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Xu LX; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Yang PY; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Chen K; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China., Bin D; Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, P. R. China., Gao TS; Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, P. R. China., Yan JY; Department of Radiation Oncology, Wuzhou Red Cross Hospital, Wuzhou, P. R. China., Chen LS; Department of Radiation Oncology, First People's Hospital of Foshan, Foshan, P. R. China., Huang SH; Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada., Zhao HY; Department of Medical Oncology and Clinical Research, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China., Hong SB; Department of Endocrinology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China., Jie YS; Department of Infectious Diseases, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China., Huang HL; Department of Cardiology, Cardiac Prevention and Assessment Center, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China., Tang XH; Department of Dermatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China., Yun JP; Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China., Liu LZ; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China., Tian L; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China., Li HJ; Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China., Li JB; Department of Clinical Research, Sun Yat-sen University Cancer Centre, Guangzhou, P. R. China. lijib@sysucc.org.cn., Zhou GQ; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China. zhougq@sysucc.org.cn., Ma J; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China. majun2@mail.sysu.edu.cn., Sun Y; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China. sunying@sysucc.org.cn.
Source: Nature [Nature] 2026 Apr; Vol. 652 (8110), pp. 731-739. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article; Clinical Trial, Phase II; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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China.<br /><searchLink fieldCode="AU" term="%22Chen+L%22">Chen L</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. China.<br /><searchLink fieldCode="AU" term="%22Mao+YP%22">Mao YP</searchLink>; Department of Radiation Oncology, Sun Yat-sen University Cancer Centre, State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Centre for Cancer, Guangzhou, P. R. 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