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Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning.

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Title: Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning.
Authors: Thornton BW; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Weissman RF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Rodriguez JE; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Tran RV; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Scribe Therapeutics, Alameda, CA, USA., Duong BT; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA., Terrace CI; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Nagalakshmi U; Department of Plant Biology, University of California, Davis, Davis, CA, USA., Austin G; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Groover ED; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA., Wang FZ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA., Park JU; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA., Georgieva V; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA., Tartaglia J; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Cho MJ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Dinesh-Kumar SP; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Plant Biology, University of California, Davis, Davis, CA, USA.; The Genome Center, University of California, Davis, Davis, CA, USA., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA.; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Savage DF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. savage@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. savage@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. savage@berkeley.edu.
Source: Nature biotechnology [Nat Biotechnol] 2026 Mar 11. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning.
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  Data: <searchLink fieldCode="AU" term="%22Thornton+BW%22">Thornton BW</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Weissman+RF%22">Weissman RF</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+JE%22">Rodriguez JE</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tran+RV%22">Tran RV</searchLink>; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Scribe Therapeutics, Alameda, CA, USA.<br /><searchLink fieldCode="AU" term="%22Duong+BT%22">Duong BT</searchLink>; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Terrace+CI%22">Terrace CI</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nagalakshmi+U%22">Nagalakshmi U</searchLink>; Department of Plant Biology, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Austin+G%22">Austin G</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Groover+ED%22">Groover ED</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+FZ%22">Wang FZ</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Park+JU%22">Park JU</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Georgieva+V%22">Georgieva V</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tartaglia+J%22">Tartaglia J</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Cho+MJ%22">Cho MJ</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dinesh-Kumar+SP%22">Dinesh-Kumar SP</searchLink>; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Plant Biology, University of California, Davis, Davis, CA, USA.; The Genome Center, University of California, Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Doudna+JA%22">Doudna JA</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA.; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Savage+DF%22">Savage DF</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. savage@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. savage@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. savage@berkeley.edu.
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