Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning.
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| Title: | Engineered TnpB genome editors for plants and human cells identified by ribonucleoprotein mutational scanning. |
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| Authors: | Thornton BW; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Weissman RF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Rodriguez JE; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Tran RV; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Scribe Therapeutics, Alameda, CA, USA., Duong BT; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA., Terrace CI; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Nagalakshmi U; Department of Plant Biology, University of California, Davis, Davis, CA, USA., Austin G; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Groover ED; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA., Wang FZ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, USA., Park JU; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA., Georgieva V; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA., Tartaglia J; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Cho MJ; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA., Dinesh-Kumar SP; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Plant Biology, University of California, Davis, Davis, CA, USA.; The Genome Center, University of California, Davis, Davis, CA, USA., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA, USA.; Li Ka Shing Center for Genomic Engineering, University of California, Berkeley, Berkeley, CA, USA.; Gladstone Institute of Data Science and Biotechnology, San Francisco, CA, USA.; Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Savage DF; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. savage@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. savage@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA, USA. savage@berkeley.edu. |
| Source: | Nature biotechnology [Nat Biotechnol] 2026 Mar 11. Date of Electronic Publication: 2026 Mar 11. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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