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SHMT2 inhibition triggers mitochondrial apoptosis to suppress lung adenocarcinoma progression.

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Title: SHMT2 inhibition triggers mitochondrial apoptosis to suppress lung adenocarcinoma progression.
Authors: Chen Y; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China., Zhang X; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China., Pang X; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China., Yang Y; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China., Lu D; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China., Zhao J; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China., Zhu J; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China., Du W; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China., Gu C; Department of Respiratory Medicine, The Second People's Hospital of Taixing, Taixing, 225400, China., Li J; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China., Gu L; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China., Huang JA; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. huang_jian_an@163.com.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China. huang_jian_an@163.com., Liu Z; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. zeyiliu@suda.edu.cn.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China. zeyiliu@suda.edu.cn., Zeng Y; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. yuanyuanzeng@suda.edu.cn.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China. yuanyuanzeng@suda.edu.cn.
Source: Journal of translational medicine [J Transl Med] 2026 Mar 11; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: SHMT2 inhibition triggers mitochondrial apoptosis to suppress lung adenocarcinoma progression.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Pang+X%22">Pang X</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Lu+D%22">Lu D</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Du+W%22">Du W</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Gu+C%22">Gu C</searchLink>; Department of Respiratory Medicine, The Second People's Hospital of Taixing, Taixing, 225400, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Gu+L%22">Gu L</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.<br /><searchLink fieldCode="AU" term="%22Huang+JA%22">Huang JA</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. huang_jian_an@163.com.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China. huang_jian_an@163.com.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. zeyiliu@suda.edu.cn.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China. zeyiliu@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China. yuanyuanzeng@suda.edu.cn.; Institute of Respiratory Diseases, Soochow University, Suzhou, 215006, China. yuanyuanzeng@suda.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Mar 11; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Mar 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12967-026-07975-9
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              Text: 2026 Mar 11
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