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Laterally spreading AAV.SPR enables safe and efficient RS1 delivery to the macula after peripheral subretinal injection.

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Title: Laterally spreading AAV.SPR enables safe and efficient RS1 delivery to the macula after peripheral subretinal injection.
Authors: Andres-Mateos E; Atsena Therapeutics, Durham, NC 27709, USA., Kozlowski C; Atsena Therapeutics, Durham, NC 27709, USA., Zhang H; Divison of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA., Fajardo D; Divison of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA., Xu E; Divison of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA., Enamorado IN; Atsena Therapeutics, Durham, NC 27709, USA., Calabro KR; Atsena Therapeutics, Durham, NC 27709, USA., Rayaprolu S; Atsena Therapeutics, Durham, NC 27709, USA., Havlik LP; Atsena Therapeutics, Durham, NC 27709, USA., Handy TE; Atsena Therapeutics, Durham, NC 27709, USA., Plummer CE; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA., Stevenson V; Ophthalmology Services, Charles River Laboratories, Mattawan, MI, USA., Rind H; Ophthalmology Services, Charles River Laboratories, Mattawan, MI, USA., Leahy M; Ophthalmology Services, Charles River Laboratories, Mattawan, MI, USA., Boyd RF; Ophthalmology Services, Charles River Laboratories, Mattawan, MI, USA., Coleman KE; Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA., Boye SL; Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA., Boye SE; Atsena Therapeutics, Durham, NC 27709, USA. Electronic address: shannon.boye@atsenatx.com.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 3838-3853. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Laterally spreading AAV.SPR enables safe and efficient RS1 delivery to the macula after peripheral subretinal injection.
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  Data: <searchLink fieldCode="AU" term="%22Andres-Mateos+E%22">Andres-Mateos E</searchLink>; Atsena Therapeutics, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Kozlowski+C%22">Kozlowski C</searchLink>; Atsena Therapeutics, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Divison of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Fajardo+D%22">Fajardo D</searchLink>; Divison of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Xu+E%22">Xu E</searchLink>; Divison of Cellular and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Enamorado+IN%22">Enamorado IN</searchLink>; Atsena Therapeutics, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Calabro+KR%22">Calabro KR</searchLink>; Atsena Therapeutics, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Rayaprolu+S%22">Rayaprolu S</searchLink>; Atsena Therapeutics, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Havlik+LP%22">Havlik LP</searchLink>; Atsena Therapeutics, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Handy+TE%22">Handy TE</searchLink>; Atsena Therapeutics, Durham, NC 27709, USA.<br /><searchLink fieldCode="AU" term="%22Plummer+CE%22">Plummer CE</searchLink>; Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Stevenson+V%22">Stevenson V</searchLink>; Ophthalmology Services, Charles River Laboratories, Mattawan, MI, USA.<br /><searchLink fieldCode="AU" term="%22Rind+H%22">Rind H</searchLink>; Ophthalmology Services, Charles River Laboratories, Mattawan, MI, USA.<br /><searchLink fieldCode="AU" term="%22Leahy+M%22">Leahy M</searchLink>; Ophthalmology Services, Charles River Laboratories, Mattawan, MI, USA.<br /><searchLink fieldCode="AU" term="%22Boyd+RF%22">Boyd RF</searchLink>; Ophthalmology Services, Charles River Laboratories, Mattawan, MI, USA.<br /><searchLink fieldCode="AU" term="%22Coleman+KE%22">Coleman KE</searchLink>; Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Boye+SL%22">Boye SL</searchLink>; Powell Gene Therapy Center, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.<br /><searchLink fieldCode="AU" term="%22Boye+SE%22">Boye SE</searchLink>; Atsena Therapeutics, Durham, NC 27709, USA. Electronic address: shannon.boye@atsenatx.com.
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  Data: <searchLink fieldCode="JN" term="%22100890581%22">Molecular therapy : the journal of the American Society of Gene Therapy</searchLink> [Mol Ther] 2026 Jul 01; Vol. 34 (7), pp. 3838-3853. <i>Date of Electronic Publication: </i>2026 Mar 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100890581 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1525-0024 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215250016%22">15250016 </searchLink><i>NLM ISO Abbreviation: </i>Mol Ther <i>Subsets: </i>MEDLINE
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              Text: 2026 Jul 01
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