Plasma neurofilament light is associated with hippocampal volume and memory performance but not functional connectivity in older adults with and without mild cognitive decline.

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Title: Plasma neurofilament light is associated with hippocampal volume and memory performance but not functional connectivity in older adults with and without mild cognitive decline.
Authors: Jung Y; Department of Psychology, Wayne State University, Detroit, MI 48202, USA.; Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA.; Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Counts SE; Departments of Translational Neuroscience and Family Medicine, Michigan State University, Grand Rapids, MI 49503, USA.; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA., Hampstead BM; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.; VA Ann Arbor Healthcare System, Neuropsychology Section, Mental Health Service, Ann Arbor, MI 48105, USA., Peltier SJ; Functional MRI Laboratory, University of Michigan, Ann Arbor, MI 48109, USA., Paulson HL; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA., Giordani B; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA., Bhaumik AK; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA., Beck JS; Departments of Translational Neuroscience and Family Medicine, Michigan State University, Grand Rapids, MI 49503, USA., Damoiseaux JS; Department of Psychology, Wayne State University, Detroit, MI 48202, USA.; Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA.; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Ben L. Silberstein Institute for Brain Health, Wayne State University, Detroit, MI 48202, USA.
Source: Aging brain [Aging Brain] 2026 Mar 04; Vol. 9, pp. 100157. Date of Electronic Publication: 2026 Mar 04 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101776137 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-9589 (Electronic) Linking ISSN: 25899589 NLM ISO Abbreviation: Aging Brain Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2589-9589
DOI:10.1016/j.nbas.2026.100157