Plasma neurofilament light is associated with hippocampal volume and memory performance but not functional connectivity in older adults with and without mild cognitive decline.

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Title: Plasma neurofilament light is associated with hippocampal volume and memory performance but not functional connectivity in older adults with and without mild cognitive decline.
Authors: Jung Y; Department of Psychology, Wayne State University, Detroit, MI 48202, USA.; Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA.; Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA., Counts SE; Departments of Translational Neuroscience and Family Medicine, Michigan State University, Grand Rapids, MI 49503, USA.; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA., Hampstead BM; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.; VA Ann Arbor Healthcare System, Neuropsychology Section, Mental Health Service, Ann Arbor, MI 48105, USA., Peltier SJ; Functional MRI Laboratory, University of Michigan, Ann Arbor, MI 48109, USA., Paulson HL; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA., Giordani B; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA., Bhaumik AK; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA., Beck JS; Departments of Translational Neuroscience and Family Medicine, Michigan State University, Grand Rapids, MI 49503, USA., Damoiseaux JS; Department of Psychology, Wayne State University, Detroit, MI 48202, USA.; Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA.; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Ben L. Silberstein Institute for Brain Health, Wayne State University, Detroit, MI 48202, USA.
Source: Aging brain [Aging Brain] 2026 Mar 04; Vol. 9, pp. 100157. Date of Electronic Publication: 2026 Mar 04 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101776137 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-9589 (Electronic) Linking ISSN: 25899589 NLM ISO Abbreviation: Aging Brain Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Plasma neurofilament light is associated with hippocampal volume and memory performance but not functional connectivity in older adults with and without mild cognitive decline.
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  Data: <searchLink fieldCode="AU" term="%22Jung+Y%22">Jung Y</searchLink>; Department of Psychology, Wayne State University, Detroit, MI 48202, USA.; Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA.; Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Counts+SE%22">Counts SE</searchLink>; Departments of Translational Neuroscience and Family Medicine, Michigan State University, Grand Rapids, MI 49503, USA.; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.<br /><searchLink fieldCode="AU" term="%22Hampstead+BM%22">Hampstead BM</searchLink>; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Research Program on Cognition and Neuromodulation Based Interventions, Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.; VA Ann Arbor Healthcare System, Neuropsychology Section, Mental Health Service, Ann Arbor, MI 48105, USA.<br /><searchLink fieldCode="AU" term="%22Peltier+SJ%22">Peltier SJ</searchLink>; Functional MRI Laboratory, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Paulson+HL%22">Paulson HL</searchLink>; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Giordani+B%22">Giordani B</searchLink>; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Bhaumik+AK%22">Bhaumik AK</searchLink>; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Beck+JS%22">Beck JS</searchLink>; Departments of Translational Neuroscience and Family Medicine, Michigan State University, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Damoiseaux+JS%22">Damoiseaux JS</searchLink>; Department of Psychology, Wayne State University, Detroit, MI 48202, USA.; Institute of Gerontology, Wayne State University, Detroit, MI 48202, USA.; Michigan Alzheimer's Disease Research Center, Ann Arbor, MI 48105, USA.; Ben L. Silberstein Institute for Brain Health, Wayne State University, Detroit, MI 48202, USA.
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  Data: <searchLink fieldCode="JN" term="%22101776137%22">Aging brain</searchLink> [Aging Brain] 2026 Mar 04; Vol. 9, pp. 100157. <i>Date of Electronic Publication: </i>2026 Mar 04 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>101776137 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-9589 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225899589%22">25899589 </searchLink><i>NLM ISO Abbreviation: </i>Aging Brain <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1016/j.nbas.2026.100157
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        Text: English
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              Text: 2026 Mar 04
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