Protective Role of Metformin in Glaucoma: Prospective Cohort Study, Meta-Analysis, and Drug-Target Mendelian Randomization.

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Title: Protective Role of Metformin in Glaucoma: Prospective Cohort Study, Meta-Analysis, and Drug-Target Mendelian Randomization.
Authors: Xue CC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Li H; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chee ML; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Soh ZD; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Yu M; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore., Lavanya R; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore., Tan NYQ; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, National University Hospital, National University Health System, Singapore., Chong R; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore.
Source: Ophthalmology science [Ophthalmol Sci] 2026 Jan 16; Vol. 6 (4), pp. 101074. Date of Electronic Publication: 2026 Jan 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 9918230896206676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-9145 (Electronic) Linking ISSN: 26669145 NLM ISO Abbreviation: Ophthalmol Sci Subsets: PubMed not MEDLINE
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  Data: Protective Role of Metformin in Glaucoma: Prospective Cohort Study, Meta-Analysis, and Drug-Target Mendelian Randomization.
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  Data: <searchLink fieldCode="AU" term="%22Xue+CC%22">Xue CC</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chee+ML%22">Chee ML</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.<br /><searchLink fieldCode="AU" term="%22Soh+ZD%22">Soh ZD</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.<br /><searchLink fieldCode="AU" term="%22Yu+M%22">Yu M</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.<br /><searchLink fieldCode="AU" term="%22Lavanya+R%22">Lavanya R</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tham+YC%22">Tham YC</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+NYQ%22">Tan NYQ</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Department of Ophthalmology, National University Hospital, National University Health System, Singapore.<br /><searchLink fieldCode="AU" term="%22Chong+R%22">Chong R</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Cheng+CY%22">Cheng CY</searchLink>; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.; Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore.
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  Data: <searchLink fieldCode="JN" term="%229918230896206676%22">Ophthalmology science</searchLink> [Ophthalmol Sci] 2026 Jan 16; Vol. 6 (4), pp. 101074. <i>Date of Electronic Publication: </i>2026 Jan 16 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%2C+B%2EV%22">Elsevier, B.V </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9918230896206676 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2666-9145 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226669145%22">26669145 </searchLink><i>NLM ISO Abbreviation: </i>Ophthalmol Sci <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Jan 16
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