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A high-throughput, quantitative platform using 2D dissociated human cerebral organoids to model neuroinflammation in Alzheimer's disease.

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Title: A high-throughput, quantitative platform using 2D dissociated human cerebral organoids to model neuroinflammation in Alzheimer's disease.
Authors: Olson MN; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Barton NJ; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Feng L; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Chigas SM; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.; Graduate Program in Neuroscience, University of Massachusetts Chan Medical School, Worcester, MA USA., Tran K; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.; Graduate Program in Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA USA., Orszulak AR; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.; Graduate Program in Immunology and Microbiology, University of Massachusetts Chan Medical School, Worcester, MA USA., Johnson JM; Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA USA., Dawes P; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Shrestha C; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Umaiyalan VR; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Huang YH; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Sundstrom J; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Murray LF; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Wang Q; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ USA., Oh HS; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA USA., Orzalli MH; Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA USA., Knipe DM; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA USA., Readhead B; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ USA., Chan Y; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Lim ET; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.
Source: NPJ dementia [NPJ Dement] 2026; Vol. 2 (1), pp. 20. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 9918993995206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 3005-1940 (Electronic) Linking ISSN: 30051940 NLM ISO Abbreviation: NPJ Dement Subsets: PubMed not MEDLINE
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  Data: A high-throughput, quantitative platform using 2D dissociated human cerebral organoids to model neuroinflammation in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Olson+MN%22">Olson MN</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Barton+NJ%22">Barton NJ</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Feng+L%22">Feng L</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Chigas+SM%22">Chigas SM</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.; Graduate Program in Neuroscience, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Tran+K%22">Tran K</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.; Graduate Program in Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Orszulak+AR%22">Orszulak AR</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.; Graduate Program in Immunology and Microbiology, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Johnson+JM%22">Johnson JM</searchLink>; Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Dawes+P%22">Dawes P</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Shrestha+C%22">Shrestha C</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Umaiyalan+VR%22">Umaiyalan VR</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Huang+YH%22">Huang YH</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Sundstrom+J%22">Sundstrom J</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Murray+LF%22">Murray LF</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ USA.<br /><searchLink fieldCode="AU" term="%22Oh+HS%22">Oh HS</searchLink>; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA USA.<br /><searchLink fieldCode="AU" term="%22Orzalli+MH%22">Orzalli MH</searchLink>; Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Knipe+DM%22">Knipe DM</searchLink>; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA USA.<br /><searchLink fieldCode="AU" term="%22Readhead+B%22">Readhead B</searchLink>; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ USA.<br /><searchLink fieldCode="AU" term="%22Chan+Y%22">Chan Y</searchLink>; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.<br /><searchLink fieldCode="AU" term="%22Lim+ET%22">Lim ET</searchLink>; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.
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  Data: <searchLink fieldCode="JN" term="%229918993995206676%22">NPJ dementia</searchLink> [NPJ Dement] 2026; Vol. 2 (1), pp. 20. <i>Date of Electronic Publication: </i>2026 Mar 09.
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