A high-throughput, quantitative platform using 2D dissociated human cerebral organoids to model neuroinflammation in Alzheimer's disease.
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| Title: | A high-throughput, quantitative platform using 2D dissociated human cerebral organoids to model neuroinflammation in Alzheimer's disease. |
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| Authors: | Olson MN; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Barton NJ; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Feng L; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Chigas SM; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.; Graduate Program in Neuroscience, University of Massachusetts Chan Medical School, Worcester, MA USA., Tran K; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.; Graduate Program in Biochemistry & Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA USA., Orszulak AR; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA.; Graduate Program in Immunology and Microbiology, University of Massachusetts Chan Medical School, Worcester, MA USA., Johnson JM; Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA USA., Dawes P; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Shrestha C; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Umaiyalan VR; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Huang YH; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Sundstrom J; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Murray LF; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Wang Q; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ USA., Oh HS; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA USA., Orzalli MH; Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, MA USA., Knipe DM; Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA USA., Readhead B; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, AZ USA., Chan Y; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA., Lim ET; Department of Medicine, Division of Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA USA.; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA USA. |
| Source: | NPJ dementia [NPJ Dement] 2026; Vol. 2 (1), pp. 20. Date of Electronic Publication: 2026 Mar 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 9918993995206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 3005-1940 (Electronic) Linking ISSN: 30051940 NLM ISO Abbreviation: NPJ Dement Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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