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Structure-Activity Relationships among Inhibitors of Acinetobacter baumannii and Klebsiella pneumoniae 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR/IspC) - A Promising Target for Antibiotic Development.

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Title: Structure-Activity Relationships among Inhibitors of Acinetobacter baumannii and Klebsiella pneumoniae 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR/IspC) - A Promising Target for Antibiotic Development.
Authors: Girma M; George Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States., Dufrisne MB; Walter Reed Army Institute of Research, Bacterial Diseases Branch, Wound Infections Department, 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Sehgal A; George Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States., Dailey A; George Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States., Heidel K; The George Washington University, Washington, District of Columbia 20052-0086, United States., Bague D; The George Washington University, Washington, District of Columbia 20052-0086, United States., Wang X; The George Washington University, Washington, District of Columbia 20052-0086, United States., Bartholomew L; The George Washington University, Washington, District of Columbia 20052-0086, United States., Beck R; The George Washington University, Washington, District of Columbia 20052-0086, United States., Kirby S; The George Washington University, Washington, District of Columbia 20052-0086, United States., Ball H; George Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States., Zainab M; George Mason University, Chemistry and Biochemistry, 10920 George Mason Circle, Fairfax, Virginia 22030-4444, United States., Lee SH; Walter Reed Army Institute of Research, Bacterial Diseases Branch, Wound Infections Department, 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Soojhawon I; Walter Reed Army Institute of Research, Bacterial Diseases Branch, Wound Infections Department, 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Noble SM; Walter Reed Army Institute of Research, Bacterial Diseases Branch, Wound Infections Department, 503 Robert Grant Ave, Silver Spring, Maryland 20910, United States., Dowd CS; The George Washington University, Washington, District of Columbia 20052-0086, United States., Couch RD; Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia 20110, United States.
Source: ACS infectious diseases [ACS Infect Dis] 2026 Jul 10; Vol. 12 (7), pp. 2203-2215. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE
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  Data: Structure-Activity Relationships among Inhibitors of Acinetobacter baumannii and Klebsiella pneumoniae 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR/IspC) - A Promising Target for Antibiotic Development.
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