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ENAC blockade reduces blood pressure and arterial stiffness in adults with obesity and insulin resistance.

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Title: ENAC blockade reduces blood pressure and arterial stiffness in adults with obesity and insulin resistance.
Authors: Padilla J; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.; Research Services, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, United States., Ramirez-Perez FI; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States., Smith JA; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States., Soares RN; Division of Kinesiology, Health, and Sports Studies, Wayne State University, Detroit, Michigan, United States., Burken M; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States., Uptergrove E; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States., Lee S; Department of Statistics and Data Science, Center for Applied Statistics and Data Analysis, University of Missouri, Columbia, Missouri, United States., Martinez-Lemus LA; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States.; Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri, United States., Manrique-Acevedo C; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.; Research Services, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, United States.; Division of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri, United States.
Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2026 Apr 01; Vol. 330 (4), pp. H1274-H1282. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ENAC blockade reduces blood pressure and arterial stiffness in adults with obesity and insulin resistance.
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  Data: <searchLink fieldCode="AU" term="%22Padilla+J%22">Padilla J</searchLink>; Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United States.; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.; Research Services, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, United States.<br /><searchLink fieldCode="AU" term="%22Ramirez-Perez+FI%22">Ramirez-Perez FI</searchLink>; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.<br /><searchLink fieldCode="AU" term="%22Smith+JA%22">Smith JA</searchLink>; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.<br /><searchLink fieldCode="AU" term="%22Soares+RN%22">Soares RN</searchLink>; Division of Kinesiology, Health, and Sports Studies, Wayne State University, Detroit, Michigan, United States.<br /><searchLink fieldCode="AU" term="%22Burken+M%22">Burken M</searchLink>; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.<br /><searchLink fieldCode="AU" term="%22Uptergrove+E%22">Uptergrove E</searchLink>; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Department of Statistics and Data Science, Center for Applied Statistics and Data Analysis, University of Missouri, Columbia, Missouri, United States.<br /><searchLink fieldCode="AU" term="%22Martinez-Lemus+LA%22">Martinez-Lemus LA</searchLink>; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.; Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, Missouri, United States.; Department of Medicine, Center for Precision Medicine, University of Missouri, Columbia, Missouri, United States.<br /><searchLink fieldCode="AU" term="%22Manrique-Acevedo+C%22">Manrique-Acevedo C</searchLink>; NextGen Precision Health, University of Missouri, Columbia, Missouri, United States.; Research Services, Harry S. Truman Memorial Veterans Hospital, Columbia, Missouri, United States.; Division of Endocrinology and Metabolism, Department of Medicine, University of Missouri, Columbia, Missouri, United States.
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  Data: <searchLink fieldCode="JN" term="%22100901228%22">American journal of physiology. Heart and circulatory physiology</searchLink> [Am J Physiol Heart Circ Physiol] 2026 Apr 01; Vol. 330 (4), pp. H1274-H1282. <i>Date of Electronic Publication: </i>2026 Mar 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901228 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1539 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203636135%22">03636135 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Heart Circ Physiol <i>Subsets: </i>MEDLINE
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        Value: 10.1152/ajpheart.00084.2026
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        Text: English
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              Text: 2026 Apr 01
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