Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial.
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| Title: | Study protocol for a multiarm, randomized controlled trial to determine the effectiveness of community-based frailty rehabilitation to improve physical function in older adults: The OPTIMAL Fitness Trial. |
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| Authors: | Papaioannou A; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Kennedy C; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Lee J; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Hewston P; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada., McArthur C; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada., Maharaj S; Hamilton Health Sciences, Hamilton, Ontario, Canada., Adachi J; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Boulos P; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Bobba R; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Rabinovich A; Department of Surgery, McMaster University, Hamilton, Ontario, Canada., McKenna B; Escarpment Health Centre, Hamilton, Ontario, Canada., Palubiski L; Escarpment Health Centre, Hamilton, Ontario, Canada., Mangin D; Department of Family Medicine, University of Otago, Christchurch, New Zealand., Thabane L; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; Biostatistics Unit, St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada.; Faculty of Health Sciences, University of Johannesburg, Johannesburg, South Africa., Marr S; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Kaasalainen S; School of Nursing, McMaster University, Hamilton, Ontario, Canada., Tarride JÉ; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Centre for Health Economics and Policy Analysis, McMaster University, Hamilton, Ontario, Canada.; Programs for Assessment of Technology in Health, The Research Institute of St. Joe's Hamilton, St. Joseph's Healthcare Hamilton, Hamilton, Canada., Theou O; School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Armstrong D; Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Negm A; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada.; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Noseworthy M; School of Biomedical Engineering, McMaster University, Hamilton, Ontario, Canada.; Department of Electrical and Computer Engineering, McMaster University, Hamilton, Ontario, Canada., Rockwood K; Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada., Dolovich L; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Abu Alrob H; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Hladysh G; School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.; YMCA of Hamilton/Burlington/Brantford, Hamilton, Ontario, Canada., Thompson K; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada., Ioannidis G; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact (HEI), McMaster University, Hamilton, Ontario, Canada.; Geras Centre for Aging Research, Hamilton Health Sciences, St. Peter's Hospital, Hamilton, Ontario, Canada. |
| Source: | PloS one [PLoS One] 2026 Mar 12; Vol. 21 (3), pp. e0343338. Date of Electronic Publication: 2026 Mar 12 (Print Publication: 2026). |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0343338 |
