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ONC206 demonstrates potent antitumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma.

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Title: ONC206 demonstrates potent antitumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma.
Authors: Tzaridis T; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Liu J; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA., Chien FL; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA., Malhotra A; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA., Zhu D; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA., Gershon I; Department of Pediatrics, Emory University, Atlanta, Georgia, USA., Zhang H; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA., Velazquez Vega JE; Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Schniederjan M; Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Sposito T; Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Stem Cell Institute, UC San Diego, La Jolla, California, USA., Adams PD; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA., Allen JE; Chimerix (a Jazz Pharmaceuticals Company), Durham, North Carolina, USA., Prabhu VV; Chimerix (a Jazz Pharmaceuticals Company), Durham, North Carolina, USA., Wechsler-Reya RJ; Department of Neurology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA., MacDonald TJ; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
Source: Neuro-oncology [Neuro Oncol] 2026 Jul 01; Vol. 28 (7), pp. 1753-1768.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ONC206 demonstrates potent antitumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Tzaridis+T%22">Tzaridis T</searchLink>; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Chien+FL%22">Chien FL</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Malhotra+A%22">Malhotra A</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+D%22">Zhu D</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Gershon+I%22">Gershon I</searchLink>; Department of Pediatrics, Emory University, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Velazquez+Vega+JE%22">Velazquez Vega JE</searchLink>; Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Schniederjan+M%22">Schniederjan M</searchLink>; Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.<br /><searchLink fieldCode="AU" term="%22Sposito+T%22">Sposito T</searchLink>; Division of Regenerative Medicine, Department of Medicine, Moores Cancer Center and Sanford Stem Cell Institute, UC San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Adams+PD%22">Adams PD</searchLink>; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Allen+JE%22">Allen JE</searchLink>; Chimerix (a Jazz Pharmaceuticals Company), Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Prabhu+VV%22">Prabhu VV</searchLink>; Chimerix (a Jazz Pharmaceuticals Company), Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Wechsler-Reya+RJ%22">Wechsler-Reya RJ</searchLink>; Department of Neurology and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22MacDonald+TJ%22">MacDonald TJ</searchLink>; Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100887420 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1523-5866 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215228517%22">15228517 </searchLink><i>NLM ISO Abbreviation: </i>Neuro Oncol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/neuonc/noag053
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              Text: 2026 Jul 01
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