High-yield trichodermin production in Trichoderma taxi via in silico-driven exporter identification and systems metabolic engineering.

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Title: High-yield trichodermin production in Trichoderma taxi via in silico-driven exporter identification and systems metabolic engineering.
Authors: Luan M; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin Economic-Technological Development Area (TEDA), No. 9, 13th Avenue, Tianjin, 300457, China., Xie B; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin Economic-Technological Development Area (TEDA), No. 9, 13th Avenue, Tianjin, 300457, China., Wan Y; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin Economic-Technological Development Area (TEDA), No. 9, 13th Avenue, Tianjin, 300457, China., Xie Z; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin Economic-Technological Development Area (TEDA), No. 9, 13th Avenue, Tianjin, 300457, China., Liu J; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin Economic-Technological Development Area (TEDA), No. 9, 13th Avenue, Tianjin, 300457, China. Electronic address: liuj@tust.edu.cn., Liu H; Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, College of Biotechnology, Tianjin University of Science and Technology, Tianjin Economic-Technological Development Area (TEDA), No. 9, 13th Avenue, Tianjin, 300457, China. Electronic address: liuhao@tust.edu.cn.
Source: Metabolic engineering [Metab Eng] 2026 Jul; Vol. 96, pp. 39-53. Date of Electronic Publication: 2026 Mar 10.
Publication Type: Journal Article
Journal Info: Publisher: Academic Press Country of Publication: Belgium NLM ID: 9815657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-7184 (Electronic) Linking ISSN: 10967176 NLM ISO Abbreviation: Metab Eng Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1096-7184
DOI:10.1016/j.ymben.2026.03.007