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Epitope-focused discovery of SARS-CoV-2 antibodies that potently neutralize Omicron variants.

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Title: Epitope-focused discovery of SARS-CoV-2 antibodies that potently neutralize Omicron variants.
Authors: Zost SJ; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Suryadevara N; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA., Williamson LE; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Scheaffer SM; Department of Medicine, Washington University School of Medicine, StLouis, MO, USA., Binshtein E; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA., Buchman CD; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA., Johnson NV; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Catanzaro NJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ravera S; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA., Chapman NS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Myers L; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA., Ramamohan AR; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Handal LS; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Nguyen DC; Department of Medicine, Emory University, Atlanta, GA, USA., Trivette A; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA., Martinez JR; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA., Villalobos E; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA., Rutherford SA; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA., Eun-Hyung Lee F; Department of Medicine, Emory University, Atlanta, GA, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA., Diamond MS; Department of Medicine, Washington University School of Medicine, StLouis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; The Andrew M. Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA., Carnahan RH; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA., Crowe JE Jr; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vumc.org.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vumc.org.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vumc.org.
Source: Nature microbiology [Nat Microbiol] 2026 Apr; Vol. 11 (4), pp. 1113-1132. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
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  Data: Epitope-focused discovery of SARS-CoV-2 antibodies that potently neutralize Omicron variants.
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  Data: <searchLink fieldCode="AU" term="%22Zost+SJ%22">Zost SJ</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Suryadevara+N%22">Suryadevara N</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Williamson+LE%22">Williamson LE</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Scheaffer+SM%22">Scheaffer SM</searchLink>; Department of Medicine, Washington University School of Medicine, StLouis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Binshtein+E%22">Binshtein E</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Buchman+CD%22">Buchman CD</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+NV%22">Johnson NV</searchLink>; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Catanzaro+NJ%22">Catanzaro NJ</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ravera+S%22">Ravera S</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Chapman+NS%22">Chapman NS</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Myers+L%22">Myers L</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Ramamohan+AR%22">Ramamohan AR</searchLink>; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Handal+LS%22">Handal LS</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+DC%22">Nguyen DC</searchLink>; Department of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Trivette+A%22">Trivette A</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+JR%22">Martinez JR</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Villalobos+E%22">Villalobos E</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rutherford+SA%22">Rutherford SA</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Eun-Hyung+Lee+F%22">Eun-Hyung Lee F</searchLink>; Department of Medicine, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Schäfer+A%22">Schäfer A</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Baric+RS%22">Baric RS</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22McLellan+JS%22">McLellan JS</searchLink>; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Diamond+MS%22">Diamond MS</searchLink>; Department of Medicine, Washington University School of Medicine, StLouis, MO, USA.; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.; The Andrew M. Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Carnahan+RH%22">Carnahan RH</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Crowe+JE+Jr%22">Crowe JE Jr</searchLink>; The Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vumc.org.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vumc.org.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. james.crowe@vumc.org.
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  Data: <searchLink fieldCode="JN" term="%22101674869%22">Nature microbiology</searchLink> [Nat Microbiol] 2026 Apr; Vol. 11 (4), pp. 1113-1132. <i>Date of Electronic Publication: </i>2026 Mar 12.
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