Lipidomic profiling in metastatic prostate cancer captures tumor metabolic rewiring and its modulation by androgen receptor-targeting therapy.

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Title: Lipidomic profiling in metastatic prostate cancer captures tumor metabolic rewiring and its modulation by androgen receptor-targeting therapy.
Authors: Bleve S; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Ravera F; Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy., Rodrigues S; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Pederzoli F; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Pakula H; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Brighi N; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Giunta EF; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Schepisi G; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Virga A; Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Gurioli G; Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Burgio SL; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Fanelli GN; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA.; Division of Pathology, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.; First Division of Pathology, Pisa University Hospital, Pisa, Italy., Butler LM; South Australian Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.; South Australian Immunogenomics Cancer Institute & Freemasons Centre for Male Health and Well-Being, Adelaide University, North Terrace, Adelaide, SA, Australia., Nanus DM; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA., Swinnen JV; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI) and Leuven Institute for Single Cell Omics (LISCO), KU Leuven, Leuven, Belgium., Nuzzo PV; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Lolli C; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., De Giorgi U; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.; Department of Experimental Medicine, University of Salento, Fazzi Hospital, Lecce, Italy., Loda M; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA. mloda@med.cornell.edu.; Nuffield Department of Surgical Sciences, Lincoln College, University of Oxford, Oxford, UK. mloda@med.cornell.edu.; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. mloda@med.cornell.edu.
Source: Prostate cancer and prostatic diseases [Prostate Cancer Prostatic Dis] 2026 Mar 13. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9815755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5608 (Electronic) Linking ISSN: 13657852 NLM ISO Abbreviation: Prostate Cancer Prostatic Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5608
DOI:10.1038/s41391-026-01100-z