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Impact of CYP2D6 Metabolizer Status on Ondansetron Efficacy in Early Pregnancy Induced Nausea and Vomiting: A Case Control Study.

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Title: Impact of CYP2D6 Metabolizer Status on Ondansetron Efficacy in Early Pregnancy Induced Nausea and Vomiting: A Case Control Study.
Authors: Liu M; Department of Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Shuey MM; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Holley SE; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Fountain DF; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Jaworski J; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Griffin C; School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kim J; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Division of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Stec M; School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Sunthankar SD; Department of Pediatrics, Pediatric Cardiology and Center for Pediatric Precision Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Ong HH; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Gangireddy S; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wei WQ; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Gaedigk A; Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Research Institute, Kansas City, Missouri, USA.; School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA., Velez Edwards DR; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Division of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Kawai VK; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Source: Clinical and translational science [Clin Transl Sci] 2026 Mar; Vol. 19 (3), pp. e70523.
Publication Type: Journal Article
Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of CYP2D6 Metabolizer Status on Ondansetron Efficacy in Early Pregnancy Induced Nausea and Vomiting: A Case Control Study.
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  Data: <searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Department of Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Shuey+MM%22">Shuey MM</searchLink>; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Holley+SE%22">Holley SE</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Fountain+DF%22">Fountain DF</searchLink>; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Jaworski+J%22">Jaworski J</searchLink>; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Griffin+C%22">Griffin C</searchLink>; School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Division of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Stec+M%22">Stec M</searchLink>; School of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Sunthankar+SD%22">Sunthankar SD</searchLink>; Department of Pediatrics, Pediatric Cardiology and Center for Pediatric Precision Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Ong+HH%22">Ong HH</searchLink>; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Gangireddy+S%22">Gangireddy S</searchLink>; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Wei+WQ%22">Wei WQ</searchLink>; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Gaedigk+A%22">Gaedigk A</searchLink>; Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Research Institute, Kansas City, Missouri, USA.; School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Velez+Edwards+DR%22">Velez Edwards DR</searchLink>; Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Division of Quantitative and Clinical Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.<br /><searchLink fieldCode="AU" term="%22Kawai+VK%22">Kawai VK</searchLink>; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
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      – TitleFull: Impact of CYP2D6 Metabolizer Status on Ondansetron Efficacy in Early Pregnancy Induced Nausea and Vomiting: A Case Control Study.
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              Text: 2026 Mar
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