Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults.

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Title: Non-linear associations of amyloid-β with resting-state functional networks and their cognitive relevance in a large community-based cohort of cognitively normal older adults.
Authors: Wu J; Department of Neurology, Emory University, 6 Executive Park Dr NE, Atlanta, GA, 30329, USA.; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA., Risk BB; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA., James TA; Department of Neurology, Emory University, 6 Executive Park Dr NE, Atlanta, GA, 30329, USA., Seyfried NT; Department of Neurology, Emory University, 6 Executive Park Dr NE, Atlanta, GA, 30329, USA.; Department of Biochemistry, Emory University, Atlanta, GA, USA., Loring DW; Department of Neurology, Emory University, 6 Executive Park Dr NE, Atlanta, GA, 30329, USA., Goldstein FC; Department of Neurology, Emory University, 6 Executive Park Dr NE, Atlanta, GA, 30329, USA., Levey AI; Department of Neurology, Emory University, 6 Executive Park Dr NE, Atlanta, GA, 30329, USA., Lah JJ; Department of Neurology, Emory University, 6 Executive Park Dr NE, Atlanta, GA, 30329, USA. jlah@emory.edu., Qiu D; Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA. dqiu3@emory.edu.; Joint Department of Biomedical Engineering, Emory University, Georgia Institute of Technology, Atlanta, GA, USA. dqiu3@emory.edu.
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Mar 12; Vol. 18 (1). Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1758-9193
DOI:10.1186/s13195-026-01986-w