Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended.

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Title: Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended.
Authors: Ma Y; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Han J; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Li Q; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Jiang X; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Li Y; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Zhang K; Department of General Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. zhangakan@163.com., Gao L; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China. linggao@sdu.edu.cn.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.
Source: Biology of sex differences [Biol Sex Differ] 2026 Mar 13; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101548963 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-6410 (Electronic) Linking ISSN: 20426410 NLM ISO Abbreviation: Biol Sex Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2042-6410
DOI:10.1186/s13293-026-00873-1