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Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended.

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Title: Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended.
Authors: Ma Y; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Han J; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Li Q; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Jiang X; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Li Y; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China., Zhang K; Department of General Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. zhangakan@163.com., Gao L; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China. linggao@sdu.edu.cn.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.
Source: Biology of sex differences [Biol Sex Differ] 2026 Mar 13; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101548963 Publication Model: Electronic Cited Medium: Internet ISSN: 2042-6410 (Electronic) Linking ISSN: 20426410 NLM ISO Abbreviation: Biol Sex Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended.
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  Data: <searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Han+J%22">Han J</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+K%22">Zhang K</searchLink>; Department of General Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. zhangakan@163.com.<br /><searchLink fieldCode="AU" term="%22Gao+L%22">Gao L</searchLink>; Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; 'Chuangxin China' Innovation Base of Stem Cell and Gene Therapy for Endocrine Metabolic Diseases, Jinan, China. linggao@sdu.edu.cn.; Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.; Shandong Engineering Research Center of Stem Cell and Gene Therapy for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. linggao@sdu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101548963%22">Biology of sex differences</searchLink> [Biol Sex Differ] 2026 Mar 13; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Mar 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101548963 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2042-6410 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220426410%22">20426410 </searchLink><i>NLM ISO Abbreviation: </i>Biol Sex Differ <i>Subsets: </i>MEDLINE
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      – TitleFull: Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended.
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