Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State.
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| Title: | Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State. |
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| Authors: | Solotchi M; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.; Graduate School of Biomedical Sciences at the Robert Wood Johnson Medical School of Rutgers University, Piscataway, NJ 08854, USA., Jing H; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Gebauer E; Structural Virology Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Novick SJ; Department of Molecular Medicine, The Wertheim UF Scripps Institute, Jupiter, FL 33458 USA., Pascal BD; Department of Molecular Medicine, The Wertheim UF Scripps Institute, Jupiter, FL 33458 USA.; Omics Informatics, Honolulu, HI 96813, USA., Tung W; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; NIH Oxford-Cambridge Scholars Program, Bethesda, MD 20892, USA., Hanpude P; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA., Madura T; School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA., Zhang Y; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Alba C; The American Genome Center, Center for Military Precision Health, Bethesda, MD 20814, USA.; Henry Jackson Foundations for the Advancement of Military Medicine, Bethesda, MD 20817, USA., Saracino A; Clinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE-J), University of Bari Aldo Moro, Bari, Italy., Laghetti P; Section of Pharmacology, Department of Precision and Regenerative Medicine and Ionian Area, School of Medicine, University of Bari Aldo Moro, Bari, Italy., Shaw ER; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Rosen LB; Immunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA., Holland SM; Immunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA., Lisco A; Mucosal and Cutaneous Viral Immunopathogenesis Unit, Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA., Dalgard CL; The American Genome Center, Center for Military Precision Health, Bethesda, MD 20814, USA.; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA., Marcotrigiano J; Structural Virology Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Griffin PR; Department of Molecular Medicine, The Wertheim UF Scripps Institute, Jupiter, FL 33458 USA., Su HC; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Patel SS; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.; Lead contact. |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2026 Mar 06. Date of Electronic Publication: 2026 Mar 06. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41822687 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Solotchi+M%22">Solotchi M</searchLink>; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.; Graduate School of Biomedical Sciences at the Robert Wood Johnson Medical School of Rutgers University, Piscataway, NJ 08854, USA.<br /><searchLink fieldCode="AU" term="%22Jing+H%22">Jing H</searchLink>; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Gebauer+E%22">Gebauer E</searchLink>; Structural Virology Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Novick+SJ%22">Novick SJ</searchLink>; Department of Molecular Medicine, The Wertheim UF Scripps Institute, Jupiter, FL 33458 USA.<br /><searchLink fieldCode="AU" term="%22Pascal+BD%22">Pascal BD</searchLink>; Department of Molecular Medicine, The Wertheim UF Scripps Institute, Jupiter, FL 33458 USA.; Omics Informatics, Honolulu, HI 96813, USA.<br /><searchLink fieldCode="AU" term="%22Tung+W%22">Tung W</searchLink>; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; NIH Oxford-Cambridge Scholars Program, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Hanpude+P%22">Hanpude P</searchLink>; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.<br /><searchLink fieldCode="AU" term="%22Madura+T%22">Madura T</searchLink>; School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Alba+C%22">Alba C</searchLink>; The American Genome Center, Center for Military Precision Health, Bethesda, MD 20814, USA.; Henry Jackson Foundations for the Advancement of Military Medicine, Bethesda, MD 20817, USA.<br /><searchLink fieldCode="AU" term="%22Saracino+A%22">Saracino A</searchLink>; Clinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area (DIMEPRE-J), University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Laghetti+P%22">Laghetti P</searchLink>; Section of Pharmacology, Department of Precision and Regenerative Medicine and Ionian Area, School of Medicine, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Shaw+ER%22">Shaw ER</searchLink>; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Rosen+LB%22">Rosen LB</searchLink>; Immunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Holland+SM%22">Holland SM</searchLink>; Immunopathogenesis Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Lisco+A%22">Lisco A</searchLink>; Mucosal and Cutaneous Viral Immunopathogenesis Unit, Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Dalgard+CL%22">Dalgard CL</searchLink>; The American Genome Center, Center for Military Precision Health, Bethesda, MD 20814, USA.; Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.<br /><searchLink fieldCode="AU" term="%22Marcotrigiano+J%22">Marcotrigiano J</searchLink>; Structural Virology Section, Laboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Griffin+PR%22">Griffin PR</searchLink>; Department of Molecular Medicine, The Wertheim UF Scripps Institute, Jupiter, FL 33458 USA.<br /><searchLink fieldCode="AU" term="%22Su+HC%22">Su HC</searchLink>; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.; NIAID Clinical Genomics Program, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Patel+SS%22">Patel SS</searchLink>; Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.; Lead contact. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2026 Mar 06. <i>Date of Electronic Publication: </i>2026 Mar 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.64898/2026.03.02.26347088 Languages: – Code: eng Text: English Titles: – TitleFull: Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Solotchi M – PersonEntity: Name: NameFull: Jing H – PersonEntity: Name: NameFull: Gebauer E – PersonEntity: Name: NameFull: Novick SJ – PersonEntity: Name: NameFull: Pascal BD – PersonEntity: Name: NameFull: Tung W – PersonEntity: Name: NameFull: Hanpude P – PersonEntity: Name: NameFull: Madura T – PersonEntity: Name: NameFull: Zhang Y – PersonEntity: Name: NameFull: Alba C – PersonEntity: Name: NameFull: Saracino A – PersonEntity: Name: NameFull: Laghetti P – PersonEntity: Name: NameFull: Shaw ER – PersonEntity: Name: NameFull: Rosen LB – PersonEntity: Name: NameFull: Holland SM – PersonEntity: Name: NameFull: Lisco A – PersonEntity: Name: NameFull: Dalgard CL – PersonEntity: Name: NameFull: Marcotrigiano J – PersonEntity: Name: NameFull: Griffin PR – PersonEntity: Name: NameFull: Su HC – PersonEntity: Name: NameFull: Patel SS IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 03 Text: 2026 Mar 06 Type: published Y: 2026 Titles: – TitleFull: MedRxiv : the preprint server for health sciences Type: main |
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