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Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification.

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Title: Shared multicellular injury programs of acute and chronic kidney disease enable mechanistic patient stratification.
Authors: Fallegger R; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Gomez-Ochoa SA; Heidelberg University Hospital, Department of General Internal Medicine and Psychosomatics, Heidelberg, Germany., Boys C; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Flores ROR; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, U.K., Tanevski J; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Pashos E; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, United States., Feliers D; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, United States., Piper M; Internal Medicine Research Unit, Pfizer Inc., Cambridge, MA, United States., Schaub JA; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA., Zhou Z; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA., Mao W; Princeton Precision Health, Princeton University, Princeton, NJ 08544, USA., Chen X; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY 10010, USA., Sealfon RSG; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY 10010, USA., Menon R; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Nair V; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Eddy S; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Alakwaa FM; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Pyle L; University of Washington Medicine Diabetes Institute, Seattle, WA 98109, USA., Choi YJ; University of Washington Medicine Diabetes Institute, Seattle, WA 98109, USA., Bjornstad P; University of Washington Medicine Diabetes Institute and Seattle Children's Research Institute, Seattle, WA 98109, USA., Alpers CE; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195., Bitzer M; University of Michigan., Bomback AS; Division of Nephrology, Columbia University Irving Medical Center, New York, NY, USA., Caramori ML; Department of Endocrinology and Metabolism, Cleveland Clinic Foundation, Cleveland, OH, USA.; Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN, USA., Demeke D; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Fogo AB; Department. Of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Herlitz LC; Cleveland Clinic., Kiryluk K; Department of Medicine, Division of Nephrology, Vagelos College of Physicians & Surgeons, Columbia University., Lash JP; Department of Medicine, University of Illinois Chicago, Chicago, Illinois., Murugan R; University of Pittsburgh., O'Toole JF; Department of Kidney Medicine, Medical Specialties Institute, Cleveland Clinic & Department of Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH., Palevsky PM; Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Parikh CR; Department of Medicine, Johns Hopkins School of Medicine, Baltimore, US., Rosas SE; Kidney and Hypertension Unit, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA., Rosenberg AZ; Department of Pathology, Johns Hopkins University School of Medicine Baltimore, MD, USA., Sedor JR; Department of Kidney Medicine, Medical Specialties Institute, Cleveland Clinic & Department of Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH., Vazquez MA; Nephrology Division, University of Texas Southwestern Medical Center., Waikar SS; Section of Nephrology, Boston Medical Center and Boston University Chobanian & Avedisian School of Medicine., Wilson FP; Clinical and Translational Research Accelerator, Department of Medicine, Yale School of Medicine, New Haven, CT., Hodgin JB; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA., Barisoni L; Department of Pathology, Division of AI & Computational Pathology, Department of Medicine, Division of Nephrology, Duke University, Durham, NC, USA., Himmelfarb J; Barbara T. Murphy Division of Nephrology, Samuel Bronfman Department of Medicine, Icahn School of Medicine at Mount Sinai., Jain S; Division of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.; Kidney Translational Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Ju W; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Troyanskaya OG; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.; Princeton Precision Health, Princeton University, Princeton, NJ 08544, USA.; Center for Computational Biology, Flatiron Institute, Simons Foundation, New York, NY 10010, USA.; Department of Computer Science, Princeton University, Princeton, NJ 08544, USA., Kretzler M; Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Co-senior authors: Matthias Kretzler, Michael T. Eadon, Julio Saez-Rodriguez., Eadon MT; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Co-senior authors: Matthias Kretzler, Michael T. Eadon, Julio Saez-Rodriguez., Saez-Rodriguez J; Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, U.K.; Co-senior authors: Matthias Kretzler, Michael T. Eadon, Julio Saez-Rodriguez.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Mar 06. Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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DbLabel: MEDLINE Ultimate
An: 41822697
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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