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Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways.

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Title: Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways.
Authors: Kunishima A; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan., Shimizu T; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan., Takimoto T; Department of Data Science, Oncology Innovation Center, Research Promotion Headquarters, Fujita Health University, Toyoake, Aichi 470‑1192, Japan., Sagara A; Department of Pharmacy, Japanese Red Cross Medical Center, Shibuya, Tokyo 150‑8935, Japan., Nobusue H; Department of Gene Regulation, Oncology Innovation Center, Research Promotion Headquarters, Fujita Health University, Toyoake, Aichi 470‑1192, Japan., Hasuwa H; Department of Collaborative Research Resources (Laboratory Animal Center), Keio University School of Medicine, Shinjuku, Tokyo 160‑8582, Japan., Hasegawa S; Department of Environmental Health Sciences, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan., Tamaoki Y; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan., Miyake H; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan., Fukuchi Y; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan., Saya H; Department of Gene Regulation, Oncology Innovation Center, Research Promotion Headquarters, Fujita Health University, Toyoake, Aichi 470‑1192, Japan., Muto A; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan.
Source: Oncology reports [Oncol Rep] 2026 May; Vol. 55 (5). Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9422756 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2431 (Electronic) Linking ISSN: 1021335X NLM ISO Abbreviation: Oncol Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways.
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  Data: <searchLink fieldCode="AU" term="%22Kunishima+A%22">Kunishima A</searchLink>; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+T%22">Shimizu T</searchLink>; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan.<br /><searchLink fieldCode="AU" term="%22Takimoto+T%22">Takimoto T</searchLink>; Department of Data Science, Oncology Innovation Center, Research Promotion Headquarters, Fujita Health University, Toyoake, Aichi 470‑1192, Japan.<br /><searchLink fieldCode="AU" term="%22Sagara+A%22">Sagara A</searchLink>; Department of Pharmacy, Japanese Red Cross Medical Center, Shibuya, Tokyo 150‑8935, Japan.<br /><searchLink fieldCode="AU" term="%22Nobusue+H%22">Nobusue H</searchLink>; Department of Gene Regulation, Oncology Innovation Center, Research Promotion Headquarters, Fujita Health University, Toyoake, Aichi 470‑1192, Japan.<br /><searchLink fieldCode="AU" term="%22Hasuwa+H%22">Hasuwa H</searchLink>; Department of Collaborative Research Resources (Laboratory Animal Center), Keio University School of Medicine, Shinjuku, Tokyo 160‑8582, Japan.<br /><searchLink fieldCode="AU" term="%22Hasegawa+S%22">Hasegawa S</searchLink>; Department of Environmental Health Sciences, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan.<br /><searchLink fieldCode="AU" term="%22Tamaoki+Y%22">Tamaoki Y</searchLink>; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan.<br /><searchLink fieldCode="AU" term="%22Miyake+H%22">Miyake H</searchLink>; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuchi+Y%22">Fukuchi Y</searchLink>; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan.<br /><searchLink fieldCode="AU" term="%22Saya+H%22">Saya H</searchLink>; Department of Gene Regulation, Oncology Innovation Center, Research Promotion Headquarters, Fujita Health University, Toyoake, Aichi 470‑1192, Japan.<br /><searchLink fieldCode="AU" term="%22Muto+A%22">Muto A</searchLink>; Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142‑8501, Japan.
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  Data: <searchLink fieldCode="JN" term="%229422756%22">Oncology reports</searchLink> [Oncol Rep] 2026 May; Vol. 55 (5). <i>Date of Electronic Publication: </i>2026 Mar 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22D%2EA%2E+Spandidos%22">D.A. Spandidos </searchLink><i>Country of Publication: </i>Greece <i>NLM ID: </i>9422756 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1791-2431 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221021335X%22">1021335X </searchLink><i>NLM ISO Abbreviation: </i>Oncol Rep <i>Subsets: </i>MEDLINE
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        Value: 10.3892/or.2026.9099
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              Text: 2026 May
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