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Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles.

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Title: Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles.
Authors: Brancolini A; Evercyte GmbH, Vienna 1110, Austria., Bobbili MR; Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Vienna, Austria; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Austria., Pultar M; TAmiRNA GmbH, Vienna 1110, Austria., Mazidi Z; Evercyte GmbH, Vienna 1110, Austria., Wieser M; Evercyte GmbH, Vienna 1110, Austria., Gamauf J; Evercyte GmbH, Vienna 1110, Austria., Roefs MT; Evercyte GmbH, Vienna 1110, Austria., Corso G; Evercyte GmbH, Vienna 1110, Austria., Nivarthi H; Evercyte GmbH, Vienna 1110, Austria., Paredes MBA; Austrian Cluster for Tissue Regeneration, Austria; Veterinary Tissue Engineering and Regenerative Medicine Group, Equine Surgery Unit, Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna 1210, Austria., Bettelheim D; Division of Obstetrics and Feto-Maternal Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna 1090, Austria., Arcalis E; Institute of Plant Biotechnology and Cell Biology (IPBT), Department of Applied Genetics and Cell Biology (DAGZ), BOKU University, Vienna, Austria., Dmitry S; School of Medical Engineering and Applied Social Science, University of Applied Sciences Upper Austria, Linz, Austria., Jacak J; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria; School of Medical Engineering and Applied Social Science, University of Applied Sciences Upper Austria, Linz, Austria., Gerner I; Austrian Cluster for Tissue Regeneration, Austria; Veterinary Tissue Engineering and Regenerative Medicine Group, Equine Surgery Unit, Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna 1210, Austria., Bileck A; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria., Gerner C; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria., Hackl M; Austrian Cluster for Tissue Regeneration, Austria; TAmiRNA GmbH, Vienna 1110, Austria., Grillari J; Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Vienna, Austria; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Austria. Electronic address: johannes.grillari@lbg.ac.at., Grillari-Voglauer R; Evercyte GmbH, Vienna 1110, Austria; Austrian Cluster for Tissue Regeneration, Austria. Electronic address: regina.grillari@evercyte.com.
Source: Journal of biotechnology [J Biotechnol] 2026 Jun; Vol. 414, pp. 124-145. Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8411927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4863 (Electronic) Linking ISSN: 01681656 NLM ISO Abbreviation: J Biotechnol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immortalization of mesenchymal stromal cells by hTERT does not affect the functional properties of secreted extracellular vesicles.
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  Data: <searchLink fieldCode="AU" term="%22Brancolini+A%22">Brancolini A</searchLink>; Evercyte GmbH, Vienna 1110, Austria.<br /><searchLink fieldCode="AU" term="%22Bobbili+MR%22">Bobbili MR</searchLink>; Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Vienna, Austria; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Austria.<br /><searchLink fieldCode="AU" term="%22Pultar+M%22">Pultar M</searchLink>; TAmiRNA GmbH, Vienna 1110, Austria.<br /><searchLink fieldCode="AU" term="%22Mazidi+Z%22">Mazidi Z</searchLink>; Evercyte GmbH, Vienna 1110, Austria.<br /><searchLink fieldCode="AU" term="%22Wieser+M%22">Wieser M</searchLink>; Evercyte GmbH, Vienna 1110, Austria.<br /><searchLink fieldCode="AU" term="%22Gamauf+J%22">Gamauf J</searchLink>; Evercyte GmbH, Vienna 1110, Austria.<br /><searchLink fieldCode="AU" term="%22Roefs+MT%22">Roefs MT</searchLink>; Evercyte GmbH, Vienna 1110, Austria.<br /><searchLink fieldCode="AU" term="%22Corso+G%22">Corso G</searchLink>; Evercyte GmbH, Vienna 1110, Austria.<br /><searchLink fieldCode="AU" term="%22Nivarthi+H%22">Nivarthi H</searchLink>; Evercyte GmbH, Vienna 1110, Austria.<br /><searchLink fieldCode="AU" term="%22Paredes+MBA%22">Paredes MBA</searchLink>; Austrian Cluster for Tissue Regeneration, Austria; Veterinary Tissue Engineering and Regenerative Medicine Group, Equine Surgery Unit, Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna 1210, Austria.<br /><searchLink fieldCode="AU" term="%22Bettelheim+D%22">Bettelheim D</searchLink>; Division of Obstetrics and Feto-Maternal Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna 1090, Austria.<br /><searchLink fieldCode="AU" term="%22Arcalis+E%22">Arcalis E</searchLink>; Institute of Plant Biotechnology and Cell Biology (IPBT), Department of Applied Genetics and Cell Biology (DAGZ), BOKU University, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Dmitry+S%22">Dmitry S</searchLink>; School of Medical Engineering and Applied Social Science, University of Applied Sciences Upper Austria, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Jacak+J%22">Jacak J</searchLink>; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria; School of Medical Engineering and Applied Social Science, University of Applied Sciences Upper Austria, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Gerner+I%22">Gerner I</searchLink>; Austrian Cluster for Tissue Regeneration, Austria; Veterinary Tissue Engineering and Regenerative Medicine Group, Equine Surgery Unit, Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna 1210, Austria.<br /><searchLink fieldCode="AU" term="%22Bileck+A%22">Bileck A</searchLink>; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gerner+C%22">Gerner C</searchLink>; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hackl+M%22">Hackl M</searchLink>; Austrian Cluster for Tissue Regeneration, Austria; TAmiRNA GmbH, Vienna 1110, Austria.<br /><searchLink fieldCode="AU" term="%22Grillari+J%22">Grillari J</searchLink>; Institute of Molecular Biotechnology, Department of Biotechnology, BOKU University, Vienna, Austria; Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Austria. Electronic address: johannes.grillari@lbg.ac.at.<br /><searchLink fieldCode="AU" term="%22Grillari-Voglauer+R%22">Grillari-Voglauer R</searchLink>; Evercyte GmbH, Vienna 1110, Austria; Austrian Cluster for Tissue Regeneration, Austria. Electronic address: regina.grillari@evercyte.com.
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  Data: <searchLink fieldCode="JN" term="%228411927%22">Journal of biotechnology</searchLink> [J Biotechnol] 2026 Jun; Vol. 414, pp. 124-145. <i>Date of Electronic Publication: </i>2026 Mar 12.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Publishers%22">Elsevier Science Publishers </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8411927 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-4863 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201681656%22">01681656 </searchLink><i>NLM ISO Abbreviation: </i>J Biotechnol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jbiotec.2026.03.010
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        Text: English
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