An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma.

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Title: An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma.
Authors: Batista MN; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Bordignon J; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA; Instituto Carlos Chagas, FIOCRUZ, Curitiba, PR, Brazil., P Mosimann AL; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA; Instituto Carlos Chagas, FIOCRUZ, Curitiba, PR, Brazil., Bobrowski T; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen HA; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Tobin-Xet G; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Barrall EA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Prokhnevska N; Department of Immunology and Immunotherapy, Marc and Jennifer Lipschultz Precision Immunology Institute, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vaidya AB; Department of Immunology and Immunotherapy, Marc and Jennifer Lipschultz Precision Immunology Institute, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lewy T; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Dinnon KH 3rd; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Seifert LL; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Zeck B; Department of Pathology, New York University Medical Center, New York, NY, USA., Quirk C; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Ho YJ; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Filliol A; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wolfisberg R; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jiang C; Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA., Cogliati B; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil., Chiriboga L; Department of Pathology, New York University Medical Center, New York, NY, USA., Theise N; Department of Pathology, New York University Medical Center, New York, NY, USA., MacDonald MR; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA., Kamphorst AO; Department of Immunology and Immunotherapy, Marc and Jennifer Lipschultz Precision Immunology Institute, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Scheel TKH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Billerbeck E; Department of Medicine, Division of Hepatology, and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA., Lowe SW; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Rosenberg BR; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: brad.rosenberg@mssm.edu., Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Electronic address: ricec@rockefeller.edu.
Source: Journal of hepatology [J Hepatol] 2026 Jun; Vol. 84 (6), pp. 1062-1076. Date of Electronic Publication: 2026 Mar 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Batista+MN%22">Batista MN</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bordignon+J%22">Bordignon J</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA; Instituto Carlos Chagas, FIOCRUZ, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22P+Mosimann+AL%22">P Mosimann AL</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA; Instituto Carlos Chagas, FIOCRUZ, Curitiba, PR, Brazil.<br /><searchLink fieldCode="AU" term="%22Bobrowski+T%22">Bobrowski T</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chen+HA%22">Chen HA</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tobin-Xet+G%22">Tobin-Xet G</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Barrall+EA%22">Barrall EA</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Prokhnevska+N%22">Prokhnevska N</searchLink>; Department of Immunology and Immunotherapy, Marc and Jennifer Lipschultz Precision Immunology Institute, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Vaidya+AB%22">Vaidya AB</searchLink>; Department of Immunology and Immunotherapy, Marc and Jennifer Lipschultz Precision Immunology Institute, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lewy+T%22">Lewy T</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dinnon+KH+3rd%22">Dinnon KH 3rd</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Seifert+LL%22">Seifert LL</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zeck+B%22">Zeck B</searchLink>; Department of Pathology, New York University Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Quirk+C%22">Quirk C</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ho+YJ%22">Ho YJ</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Filliol+A%22">Filliol A</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wolfisberg+R%22">Wolfisberg R</searchLink>; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jiang+C%22">Jiang C</searchLink>; Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cogliati+B%22">Cogliati B</searchLink>; Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Chiriboga+L%22">Chiriboga L</searchLink>; Department of Pathology, New York University Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Theise+N%22">Theise N</searchLink>; Department of Pathology, New York University Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22MacDonald+MR%22">MacDonald MR</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kamphorst+AO%22">Kamphorst AO</searchLink>; Department of Immunology and Immunotherapy, Marc and Jennifer Lipschultz Precision Immunology Institute, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Scheel+TKH%22">Scheel TKH</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA; Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Sheahan+TP%22">Sheahan TP</searchLink>; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Billerbeck+E%22">Billerbeck E</searchLink>; Department of Medicine, Division of Hepatology, and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rosenberg+BR%22">Rosenberg BR</searchLink>; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: brad.rosenberg@mssm.edu.<br /><searchLink fieldCode="AU" term="%22Rice+CM%22">Rice CM</searchLink>; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA. Electronic address: ricec@rockefeller.edu.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2026 Jun; Vol. 84 (6), pp. 1062-1076. <i>Date of Electronic Publication: </i>2026 Mar 11.
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