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EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2025 update.

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Title: EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2025 update.
Authors: Smolen JS; Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria. Electronic address: josef.smolen@meduniwien.ac.at., Edwards CJ; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Konzett V; Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria., Laskou F; MRC Lifecourse Epidemiology Centre, Southampton, UK., Aletaha D; Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria., Caporali R; Department of Clinical Science and Community Health, University of Milan, Milan, Italy; Department of Rheumatology and Medical Sciences, ASST Pini-CTO, Milan, Italy., Dörner T; Department of Medicine/Rheumatology and Clinical Immunology, Charite Universitätsmedizin Berlin & Deutsches Rheumaforschungszentrum (DRFZ), Berlin, Germany., Hyrich KL; Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK; National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK., Mateus E; Portuguese League Against Rheumatic Diseases (LPCDR), Lisbon, Portugal., Pope JE; Schulich School of Medicine, University of Western Ontario, London, ON, Canada., Primdahl J; Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg, Denmark., de Souza S; Clinical Research Facility, King's College Hospital, London, UK., Stamm T; Institute of Outcomes Research, Centre for Medical Data Science, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria., Takeuchi T; Department of Rheumatology and Applied Immunology/Clinical Immunology, Saitama Medical University, Saitama, Japan., van der Heijde D; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands., Verschueren P; Department of Rheumatology, University Hospitals Leuven, Leuven, Belgium., Winthrop KL; School of Public Health, Oregon Health & Science University, Portland, OR, USA., Alvaro-Gracia JM; Rheumatology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Universidad Computense, Madrid, Spain., Askling J; Departement of Medicine Solna, Karolinska Institutet, Stockholm, Sweden., Bathon J; Division of Rheumatology, Columbia University Irving Medical Center, New York, NY, USA., Buch MH; Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK; National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK., Burmester GR; Department Medicine/Rheumatology and Clinical Immunology, Charite Universitätsmedizin Berlin, Berlin, Germany., Codreanu C; Center for Rheumatic Diseases University of Medicine and Pharmacy, Bucharest, Romania., Conaghan PG; Leeds Institute of Rheumatic & Musculoskeletal Medicine, University of Leeds, Leeds, UK; NIHR Leeds Biomedical Research Centre, University of Leeds, Leeds, UK., Cutolo M; Laboratory of Experimental Rheumatology, Division of Rheumatology, Department of Internal Medicine - DiMI, University of Genova, Genova, Italy., Fautrel B; Sorbonne Université-APHP, Service de Rhumatologie, FCRIN CRI-IMIDIATE Clinical Research Network, Hôpital de la Pitié-Salpêtrière, Paris, France; INSERM UMRS 1136, Paris, France., Fonseca J; Faculdade de Medicina, Universidade de Lisboa, Centro Académico de Medicina de Lisboa, Lisbon, Portugal; ULS Santa Maria, Centro Académico de Medicina de Lisboa, Lisbon, Portugal., Gossec L; Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Team Pepites, Paris, France; AP-HP, Pitié-Salpêtrière hospital, Rheumatology Department, Paris, France., Haavardsholm E; Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway., Hetland ML; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Iagnocco A; Academic Rheumatology Center, University of Turin, AO Mauriziano, Turin, Italy., Juge PA; Service de Rhumatologie, Hôpital Bichat-Claude Bernard, AP-HP, Paris, France; Université de Paris, INSERM U-1153, Centre de recherche en épidémiologie et statistiques, Paris, France., Li Z; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, People's Republic of China; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Peking University People's Hospital, Beijing, People's Republic of China., Moe RH; Health Services and Innovation Unit & Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway., Nash P; School of Medicine, Griffith University, Brisbane, QLD, Australia., Poór G; Department of Rheumatology and Immunology Semmelweis University, Budapest, Hungary., Rubbert-Roth A; Cantonal Hospital St Gallen, HOCH Health Ostschweiz, St Gallen, Switzerland., Sobrin RDS; Clinical University Hospital in Santiago de Compostela and Health Research Institute in Santiago de Compostela, A Coruña, Spain., Schulze-Koops H; Division of Rheumatology and Clinical Immunology, Department of Medicine IV. LMU University Hospital, Munich, Germany., Shumnalieva R; Department of Rheumatology, Clinic of Rheumatology, University Hospital 'St. Anna' Sofia, Medical University-Sofia, Sofia, Bulgaria., Senolt L; Institute of Rheumatology, and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic., Silva-Fernandez L; Servicio de Reumatología, Complexo Hospitalario Universitario de Pontevedra, Pontevedra, Spain., Strangfeld A; Programme Area Epidemiology and Health Services Research, German Rheumatology Research Center, Berlin, Germany; Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany., Taylor P; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Turesson C; Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden., van Duuren E; The Sefako Makgatho Health Science University, Pretoria, South Africa., de Wit M; EULAR Patient Research Partner, Amsterdam, Netherlands., Xavier R; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Kerschbaumer A; Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria; Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Landewé RBM; Amsterdam University Medical Center, Amsterdam and Zuyderland MC, Heerlen, The Netherlands.
Source: Annals of the rheumatic diseases [Ann Rheum Dis] 2026 Jun; Vol. 85 (6), pp. 991-1009. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Consensus Statement; Journal Article
Journal Info: Publisher: BMJ Country of Publication: United States NLM ID: 0372355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2060 (Electronic) Linking ISSN: 00034967 NLM ISO Abbreviation: Ann Rheum Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2025 update.
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  Data: <searchLink fieldCode="AU" term="%22Smolen+JS%22">Smolen JS</searchLink>; Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria. 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Department of Medicine/Rheumatology and Clinical Immunology, Charite Universitätsmedizin Berlin & Deutsches Rheumaforschungszentrum (DRFZ), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hyrich+KL%22">Hyrich KL</searchLink>; Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK; National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Mateus+E%22">Mateus E</searchLink>; Portuguese League Against Rheumatic Diseases (LPCDR), Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Pope+JE%22">Pope JE</searchLink>; Schulich School of Medicine, University of Western Ontario, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Primdahl+J%22">Primdahl J</searchLink>; Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg, Denmark.<br /><searchLink fieldCode="AU" term="%22de+Souza+S%22">de Souza S</searchLink>; Clinical Research Facility, King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Stamm+T%22">Stamm T</searchLink>; Institute of Outcomes Research, Centre for Medical Data Science, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Takeuchi+T%22">Takeuchi T</searchLink>; Department of Rheumatology and Applied Immunology/Clinical Immunology, Saitama Medical University, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22van+der+Heijde+D%22">van der Heijde D</searchLink>; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Verschueren+P%22">Verschueren P</searchLink>; Department of Rheumatology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Winthrop+KL%22">Winthrop KL</searchLink>; School of Public Health, Oregon Health & Science University, Portland, OR, USA.<br /><searchLink fieldCode="AU" term="%22Alvaro-Gracia+JM%22">Alvaro-Gracia JM</searchLink>; Rheumatology Department, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Universidad Computense, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Askling+J%22">Askling J</searchLink>; Departement of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bathon+J%22">Bathon J</searchLink>; Division of Rheumatology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Buch+MH%22">Buch MH</searchLink>; Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK; National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Burmester+GR%22">Burmester GR</searchLink>; Department Medicine/Rheumatology and Clinical Immunology, Charite Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Codreanu+C%22">Codreanu C</searchLink>; 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Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Team Pepites, Paris, France; AP-HP, Pitié-Salpêtrière hospital, Rheumatology Department, Paris, France.<br /><searchLink fieldCode="AU" term="%22Haavardsholm+E%22">Haavardsholm E</searchLink>; Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Hetland+ML%22">Hetland ML</searchLink>; Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Iagnocco+A%22">Iagnocco A</searchLink>; Academic Rheumatology Center, University of Turin, AO Mauriziano, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Juge+PA%22">Juge PA</searchLink>; Service de Rhumatologie, Hôpital Bichat-Claude Bernard, AP-HP, Paris, France; Université de Paris, INSERM U-1153, Centre de recherche en épidémiologie et statistiques, Paris, France.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, People's Republic of China; Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Peking University People's Hospital, Beijing, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Moe+RH%22">Moe RH</searchLink>; Health Services and Innovation Unit & Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Nash+P%22">Nash P</searchLink>; School of Medicine, Griffith University, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Poór+G%22">Poór G</searchLink>; Department of Rheumatology and Immunology Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Rubbert-Roth+A%22">Rubbert-Roth A</searchLink>; Cantonal Hospital St Gallen, HOCH Health Ostschweiz, St Gallen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sobrin+RDS%22">Sobrin RDS</searchLink>; Clinical University Hospital in Santiago de Compostela and Health Research Institute in Santiago de Compostela, A Coruña, Spain.<br /><searchLink fieldCode="AU" term="%22Schulze-Koops+H%22">Schulze-Koops H</searchLink>; Division of Rheumatology and Clinical Immunology, Department of Medicine IV. 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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1468-2060
          Numbering:
            – Type: volume
              Value: 85
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Annals of the rheumatic diseases
              Type: main
ResultId 1