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Evaluation of sNfL as a Biomarker for Paclitaxel-Induced Peripheral Neurotoxicity Through an Integrated PKPD Model.

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Title: Evaluation of sNfL as a Biomarker for Paclitaxel-Induced Peripheral Neurotoxicity Through an Integrated PKPD Model.
Authors: Ibrahim EIK; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Girdenyté M; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Pharmacy and Pharmacology Center, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania., Hu Y; Department of Pharmacy, Uppsala University, Uppsala, Sweden.; Non-Clinical Safety & DMPK, BioNTech SE, Mainz, Germany., Di Cesare Mannelli L; Department of Neuroscience, Psychology, Drug Research and Child Health - Neurofarba - Section of Pharmacology and Toxicology, University of Florence, Florence, Italy., Balayssac D; Direction de La Recherche Clinique Et de L'Innovation, Université Clermont Auvergne, INSERM, NEURO-DOL, CHU Clermont-Ferrand, Clermont-Ferrand, U1107, France., Busserolles J; Université Clermont Auvergne, INSERM, NEURO-DOL, Clermont-Ferrand, U1107, France., Theil D; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.; Roche Pharmaceutical Research and Early Development , Roche Innovation Center, Basel, Switzerland., Roussignol G; Preclinical Safety, Sanofi, R&D, Montpellier, France., Perrault O; Preclinical Safety, Sanofi, R&D, Montpellier, France., Le Berre N; Preclinical Safety, Sanofi, R&D, Montpellier, France., Chanut F; Preclinical Safety, Sanofi, R&D, Chilly Mazarin & Vitry, France., Slaoui M; Preclinical Safety, Sanofi, R&D, Vitry, France., Loryan I; Department of Pharmacy, Uppsala University, Uppsala, Sweden. irena.loryan@uu.se., Friberg LE; Department of Pharmacy, Uppsala University, Uppsala, Sweden. lena.friberg@uu.se.
Source: Pharmaceutical research [Pharm Res] 2026 Apr; Vol. 43 (4), pp. 1071-1088. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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